HitPredict

Interactor 1: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Interactor 2: MED15 (Q96RN5)
Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein)
Gene: MED15

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29509190
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 530 Hs			1 788
+	Hs
		370253 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		MED15_HUMAN (1-788): 2.62e-102: 335: 100.00
+	Hs
		302306 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		SC31A_HUMAN (137-649): 5.31e-32: 136: 16.60
+	Hs
		1233527 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		MINK1_HUMAN (173-542): 1.75e-26: 118: 18.18
+	Hs
		1270056 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		CABIN_HUMAN (72-522): 6.45e-26: 117: 11.50
+	Hs
		554348 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		MUC1_HUMAN (72-625): 3.94e-26: 117: 8.26
+	Hs
		160119 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		HGS_HUMAN (71-479): 3.22e-23: 107: 18.08
+	Hs
		867111 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		SC24C_HUMAN (262-514): 3.21e-14: 78.9: 18.82
+	Hs
		1264774 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		TITIN_HUMAN (156-460): 5.01e-12: 72.4: 11.53
+	Hs
		369994 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		MINK1_HUMAN (173-542): 1.75e-26: 118: 18.18
+	Hs
		368927 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		MUC1_HUMAN (72-625): 3.94e-26: 117: 8.26
+	Hs
		1269276 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24
+	Hs
		1269810 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		CHD7_HUMAN (63-279): 3.68e-09: 62.8: 15.07
+	Hs
		1270066 ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00		PCLO_HUMAN (77-680): 9.36e-09: 61.7: 9.36
+	Hs
		370225 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		EP400_HUMAN (236-579): 1.3e-19: 97: 20.00
+	Hs
		370105 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		TITIN_HUMAN (156-460): 5.01e-12: 72.4: 11.53
+	Hs
		370136 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24
+	Hs
		370607 ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56		CHD7_HUMAN (63-279): 3.68e-09: 62.8: 15.07
+	Mm
		101423 ESR1_MOUSE (9-529): 4.88e-134: 403: 43.72		F8VPR5_MOUSE (147-583): 8.96e-10: 64.8: 11.19
+	Hs
		587190 RXRA_HUMAN (13-502): 1.6e-119: 361: 25.71		CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24
+	Mm
		101427 RXRG_MOUSE (13-499): 5.3e-117: 355: 22.56		F8VPR5_MOUSE (147-583): 8.96e-10: 64.8: 11.19