HitPredict

Interactor 1: CYFP1 (Q7L576)
Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1)
Gene: CYFIP1

Interactor 2: ABI3 (Q9P2A4)
ABI gene family member 3 (New molecule including SH3) (Nesh)
Gene: ABI3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Abi_HHR~FragX_IP
Common GO terms	GO:0030027 - lamellipodium GO:0031209 - SCAR complex GO:0051015 - actin filament binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1253 Hs			1 366
+	Mm
		976080 CYFP2_MOUSE (1-1253): 0: 2078: 87.55		ABI2_MOUSE (1-363): 1.19e-86: 270: 34.40
+	Hs
		1390221 CYFP2_HUMAN (1-1253): 0: 2070: 85.92		ABI3_HUMAN (1-366): 5.41e-88: 271: 100.00
+	Mm
		1274195 CYFP1_MOUSE (1-1253): 0: 2079: 99.04		ABI1_MOUSE (1-314): 3.09e-64: 213: 34.35
+	Mm
		1210215 CYFP2_MOUSE (1-1253): 0: 2078: 87.55		ABI1_MOUSE (1-314): 3.09e-64: 213: 34.35
+	Mm
		1210156 CYFP2_MOUSE (1-1253): 0: 2078: 87.55		SRC8_MOUSE (40-363): 6.97e-42: 155: 13.44
+	Hs
		1390225 CYFP2_HUMAN (1-1253): 0: 2070: 85.92		PACN2_HUMAN (17-363): 4.81e-45: 162: 14.29
+	Hs
		1390209 CYFP2_HUMAN (1-1253): 0: 2070: 85.92		PACN1_HUMAN (11-363): 1.32e-37: 142: 12.67
+	Hs
		1272213 CYFP1_HUMAN (1-1253): 0: 2086: 100.00		ABI2_HUMAN (109-363): 1.97e-25: 108: 23.18
+	Hs
		1272177 CYFP1_HUMAN (1-1253): 0: 2086: 100.00		ABI1_HUMAN (124-363): 6.4e-21: 95.9: 24.49
+	Hs
		1390217 CYFP2_HUMAN (1-1253): 0: 2070: 85.92		ABI2_HUMAN (109-363): 1.97e-25: 108: 23.18
+	Hs
		1316694 CYFP2_HUMAN (1-1253): 0: 2070: 85.92		ABI1_HUMAN (124-363): 6.4e-21: 95.9: 24.49
+	Hs
		987855 CYFP2_HUMAN (1-1253): 0: 2070: 85.92		GRB2_HUMAN (312-363): 4.05e-14: 72.7: 28.30
+	Dm
		1473655 CYFIP_DROME (1-1253): 0: 1903: 65.73		Q9Y0S9_DROME (260-364): 6.86e-21: 95.5: 38.32
+	Dd
		1200911 PIRA_DICDI (4-1225): 0: 1461: 37.60		ABIA_DICDI (3-321): 7.75e-30: 119: 19.32