HitPredict

Interactor 1: LEG8 (O00214)
Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1)
Gene: LGALS8

Interactor 2: ITA4 (P13612)
Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d)
Gene: ITGA4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.721

Property	Details
Experiments	26186194, 28514442, 33961781, 10852818, 18024965
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005178 - integrin binding GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 317 Hs			1 1032
+	Hs
		125195 LEG9_HUMAN (3-316): 1.75e-113: 334: 30.83		ITA4_HUMAN (1-1032): 0: 1246: 100.00
+	Hs
		480676 LEG1_HUMAN (27-151): 4.33e-38: 133: 28.13		ITA4_HUMAN (1-1032): 0: 1246: 100.00
+	Hs
		127278 LEG8_HUMAN (1-317): 8.01e-137: 392: 100.00		ITA6_HUMAN (14-1009): 0: 867: 24.46
+	Hs
		127326 LEG8_HUMAN (1-317): 8.01e-137: 392: 100.00		ITA7_HUMAN (1-1009): 0: 863: 24.52
+	Hs
		127247 LEG8_HUMAN (1-317): 8.01e-137: 392: 100.00		ITAV_HUMAN (31-1007): 0: 862: 25.46
+	Hs
		127253 LEG8_HUMAN (1-317): 8.01e-137: 392: 100.00		ITA5_HUMAN (33-1017): 0: 862: 24.90
+	Hs
		127281 LEG8_HUMAN (1-317): 8.01e-137: 392: 100.00		ITA3_HUMAN (1-1021): 0: 818: 22.87
+	Hs
		125162 LEG9_HUMAN (3-316): 1.75e-113: 334: 30.83		ITA5_HUMAN (33-1017): 0: 862: 24.90
+	Mm
		147612 LEG9_MOUSE (3-316): 2.25e-118: 346: 34.08		ITA2B_MOUSE (27-1012): 0: 774: 26.20
+	Hs
		609576 LEG3_HUMAN (16-153): 1.93e-46: 159: 39.72		ITA6_HUMAN (14-1009): 0: 867: 24.46
+	Hs
		473654 LEG3_HUMAN (16-153): 1.93e-46: 159: 39.72		ITA5_HUMAN (33-1017): 0: 862: 24.90
+	Hs
		447961 LEG1_HUMAN (27-151): 4.33e-38: 133: 28.13		ITAV_HUMAN (31-1007): 0: 862: 25.46
+	Hs
		473644 LEG1_HUMAN (27-151): 4.33e-38: 133: 28.13		ITA5_HUMAN (33-1017): 0: 862: 24.90
+	Hs
		127308 LEG8_HUMAN (1-317): 8.01e-137: 392: 100.00		ITA1_HUMAN (1-186): 1.05e-41: 168: 25.67
+	Hs
		127272 LEG8_HUMAN (1-317): 8.01e-137: 392: 100.00		ITA2_HUMAN (27-183): 2.05e-34: 145: 28.30
+	Hs
		127277 LEG8_HUMAN (1-317): 8.01e-137: 392: 100.00		ITAL_HUMAN (12-183): 1.19e-15: 84.4: 21.02
+	Hs
		125225 LEG9_HUMAN (3-316): 1.75e-113: 334: 30.83		ITAL_HUMAN (12-183): 1.19e-15: 84.4: 21.02
+	Hs
		609640 LEG3_HUMAN (16-153): 1.93e-46: 159: 39.72		ITA1_HUMAN (1-186): 1.05e-41: 168: 25.67
+	Hs
		603744 LEG3_HUMAN (16-153): 1.93e-46: 159: 39.72		ITA2_HUMAN (27-183): 2.05e-34: 145: 28.30
+	Hs
		539456 LEG3_HUMAN (16-153): 1.93e-46: 159: 39.72		ITAM_HUMAN (22-185): 1.4e-26: 119: 24.39