HitPredict

Interactor 1: MED8 (Q96G25)
Mediator of RNA polymerase II transcription subunit 8 (Activator-recruited cofactor 32 kDa component) (ARC32) (Mediator complex subunit 8)
Gene: MED8

Interactor 2: CDK19 (Q9BWU1)
Cyclin-dependent kinase 19 (EC 2.7.11.22) (CDC2-related protein kinase 6) (Cell division cycle 2-like protein kinase 6) (Cell division protein kinase 19) (Cyclin-dependent kinase 11) (Death-preventing kinase)
Gene: CDK19

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	24981860, 26186194, 28514442, 33961781, 32707033, 23602568
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 268 Hs			1 502
+	Hs
		826334 MED8_HUMAN (1-268): 1.09e-149: 420: 100.00		CDK8_HUMAN (1-502): 1.77e-150: 439: 76.69
+	Hs
		73036 MED8_HUMAN (1-268): 1.09e-149: 420: 100.00		B4DUB1_HUMAN (152-502): 1.59e-138: 406: 100.00
+	Dm
		56322 MED8_DROME (1-268): 4.04e-113: 327: 43.22		CDK8_DROME (1-413): 7.19e-138: 407: 77.24