HitPredict

Interactor 1: DTX1 (Q86Y01)
E3 ubiquitin-protein ligase DTX1 (EC 2.3.2.27) (Protein deltex-1) (Deltex1) (hDTX1) (RING-type E3 ubiquitin transferase DTX1)
Gene: DTX1

Interactor 2: UB2D4 (Q9Y2X8)
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)
Gene: UBE2D4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	19690564
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 620 Hs			1 147
+	Hs
		906697 DTX1_HUMAN (1-620): 0: 896: 100.00		UB2D1_HUMAN (1-147): 3.33e-83: 242: 91.84
+	Hs
		982233 DTX1_HUMAN (1-620): 0: 896: 100.00		UB2D2_HUMAN (1-147): 7.67e-83: 241: 93.20
+	Hs
		957126 DTX1_HUMAN (1-620): 0: 896: 100.00		UB2D3_HUMAN (1-147): 8.57e-82: 238: 91.84
+	Hs
		909342 DTX1_HUMAN (1-620): 0: 896: 100.00		UB2E1_HUMAN (4-146): 3.9e-73: 218: 64.34
+	Hs
		957781 DTX1_HUMAN (1-620): 0: 896: 100.00		UBE2N_HUMAN (4-147): 2.31e-69: 207: 46.53
+	Hs
		1289342 DTX2_HUMAN (9-615): 0: 830: 45.66		UB2D4_HUMAN (1-147): 4.38e-84: 244: 100.00
+	Hs
		906692 DTX2_HUMAN (9-615): 0: 830: 45.66		UB2D1_HUMAN (1-147): 3.33e-83: 242: 91.84
+	Hs
		982229 DTX2_HUMAN (9-615): 0: 830: 45.66		UB2D2_HUMAN (1-147): 7.67e-83: 241: 93.20
+	Hs
		957122 DTX2_HUMAN (9-615): 0: 830: 45.66		UB2D3_HUMAN (1-147): 8.57e-82: 238: 91.84
+	Hs
		1350958 DTX3L_HUMAN (341-613): 1e-113: 358: 34.41		UB2D4_HUMAN (1-147): 4.38e-84: 244: 100.00
+	Hs
		906716 DTX3L_HUMAN (341-613): 1e-113: 358: 34.41		UB2D1_HUMAN (1-147): 3.33e-83: 242: 91.84
+	Hs
		982257 DTX3L_HUMAN (341-613): 1e-113: 358: 34.41		UB2D2_HUMAN (1-147): 7.67e-83: 241: 93.20
+	Hs
		957143 DTX3L_HUMAN (341-613): 1e-113: 358: 34.41		UB2D3_HUMAN (1-147): 8.57e-82: 238: 91.84
+	Hs
		1350942 DTX3L_HUMAN (341-613): 1e-113: 358: 34.41		UB2E2_HUMAN (4-146): 2.83e-75: 224: 64.34
+	Hs
		1350938 DTX3L_HUMAN (341-613): 1e-113: 358: 34.41		UB2E3_HUMAN (4-146): 1.06e-74: 223: 64.34
+	Hs
		909356 DTX3L_HUMAN (341-613): 1e-113: 358: 34.41		UB2E1_HUMAN (4-146): 3.9e-73: 218: 64.34
+	Hs
		906708 DTX3_HUMAN (408-615): 6.43e-84: 268: 34.91		UB2D1_HUMAN (1-147): 3.33e-83: 242: 91.84
+	Hs
		957133 DTX3_HUMAN (408-615): 6.43e-84: 268: 34.91		UB2D3_HUMAN (1-147): 8.57e-82: 238: 91.84
+	Hs
		909351 DTX3_HUMAN (408-615): 6.43e-84: 268: 34.91		UB2E1_HUMAN (4-146): 3.9e-73: 218: 64.34
+	Hs
		957792 DTX3_HUMAN (408-615): 6.43e-84: 268: 34.91		UBE2N_HUMAN (4-147): 2.31e-69: 207: 46.53