Protein: DTX3L
E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2)

Gene: DTX3L
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q8TDB6

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0002230 - positive regulation of defense response to virus by host
GO:0004842 - ubiquitin-protein transferase activity
GO:0004857 - enzyme inhibitor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1350933

DTX3L
E3 ubiquitin-protein ligase DTX3L

5

7

Small-scale

0.930

High

906716

UB2D1
Ubiquitin-conjugating enzyme E2 D1

5

20

Small-scale

0.922

High

982257

UB2D2
Ubiquitin-conjugating enzyme E2 D2

3

20

Small-scale

0.854

High

957143

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.793

High

957632

UBE2K
Ubiquitin-conjugating enzyme E2 K

2

20

High-throughput

0.783

High

1312889

PARP9
Protein mono-ADP-ribosyltransferase PARP9

12

7

Small-scale

0.759

High

909356

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

High-throughput

0.698

High

970820

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.698

High

993665

UBC9
SUMO-conjugating enzyme UBC9

1

20

High-throughput

0.698

High

1258784

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

16

High-throughput

0.698

High

1350938

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

High-throughput

0.698

High

1350939

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

1350942

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

20

High-throughput

0.698

High

1350947

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

4

High-throughput

0.698

High

1350958

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

449760

H2B1J
Histone H2B type 1-J

1

0

Small-scale

0.687

High

1350952

SPG21
Maspardin

3

1

High-throughput

0.675

High

1259619

H2AV
Histone H2A.V

1

2

Small-scale

0.647

High

714289

PML
Protein PML

1

2

High-throughput

0.618

High

1294443

DTX1
E3 ubiquitin-protein ligase DTX1

1

7

Small-scale

0.618

High

1350956

DTX4
E3 ubiquitin-protein ligase DTX4

1

7

Small-scale

0.618

High

419098

H2A1B
Histone H2A type 1-B/E

1

0

Small-scale

0.614

High

838143

STAT1
Signal transducer and activator of transcription 1-alpha/beta

2

2

Small-scale

0.584

High

1192950

PAR14
Protein mono-ADP-ribosyltransferase PARP14

2

7

Small-scale

0.584

High

980030

H4
Histone H4

1

1

Small-scale

0.561

High

1350941

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

1

Small-scale

0.561

High

1252755

RN111
E3 ubiquitin-protein ligase Arkadia

1

1

High-throughput

0.541

High

1350946

PHF7
E3 ubiquitin-protein ligase PHF7

1

2

High-throughput

0.541

High

75518

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

723945

LCN1
Lipocalin-1

1

0

High-throughput

0.513

High

1350955

DP13A
DCC-interacting protein 13-alpha

1

0

High-throughput

0.513

High

656200

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

0

High-throughput

0.493

High

169665

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

3

Small-scale

0.479

High

253367

JAK2
Tyrosine-protein kinase JAK2

1

9

Small-scale

0.479

High

520218

ANDR
Androgen receptor

1

1

Small-scale

0.479

High

531112

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

1

High-throughput

0.479

High

589233

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

658742

JAK1
Tyrosine-protein kinase JAK1

1

8

Small-scale

0.479

High

696016

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

768715

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

1047655

NOTC2
Neurogenic locus notch homolog protein 2

1

7

Small-scale

0.479

High

1100915

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.479

High

1113792

CUL3
Cullin-3

1

3

High-throughput

0.479

High

1141811

EEA1
Early endosome antigen 1

1

1

High-throughput

0.479

High

1227116

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

1254769

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1350935

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1350936

HDAC2
Histone deacetylase 2

1

2

High-throughput

0.479

High

1350937

STAM1
Signal transducing adapter molecule 1

1

4

Small-scale

0.479

High

1350940

PDLI5
PDZ and LIM domain protein 5

1

1

Small-scale

0.479

High

1350943

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

1

Small-scale

0.479

High

1350953

DJB11
DnaJ homolog subfamily B member 11

1

1

High-throughput

0.479

High

1350954

TBK1
Serine/threonine-protein kinase TBK1

1

3

Small-scale

0.479

High

160113

CHD1
Chromodomain-helicase-DNA-binding protein 1

1

0

High-throughput

0.458

High

217490

E41L2
Band 4.1-like protein 2

1

0

Small-scale

0.458

High

582186

INGR1
Interferon gamma receptor 1

1

0

Small-scale

0.458

High

831106

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

947478

RAB15
Ras-related protein Rab-15

1

0

High-throughput

0.458

High

1004876

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1045554

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1252905

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

1330882

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

1350945

CND3
Condensin complex subunit 3

1

0

Small-scale

0.458

High

1350949

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

0

Small-scale

0.458

High

391373

FRIL
Ferritin light chain

1

1

High-throughput

0.445

High

756283

MCM7
DNA replication licensing factor MCM7

1

1

Small-scale

0.445

High

896421

ERF
ETS domain-containing transcription factor ERF

1

1

High-throughput

0.445

High

1350934

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.445

High

1350944

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

1350948

PAR12
Protein mono-ADP-ribosyltransferase PARP12

1

7

High-throughput

0.445

High

1350951

GLOD4
Glyoxalase domain-containing protein 4

1

1

Small-scale

0.437

High

384703

CRYAB
Alpha-crystallin B chain

1

0

High-throughput

0.426

High

848806

MAGAA
Melanoma-associated antigen 10

1

0

High-throughput

0.426

High

1239255

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.426

High

437746

HEPS
Serine protease hepsin

1

1

High-throughput

0.407

High

1328103

TTC9C
Tetratricopeptide repeat protein 9C

1

1

High-throughput

0.407

High

1254109

RBM43
RNA-binding protein 43

1

0

High-throughput

0.279

Low

1350950

ANTR1
Anthrax toxin receptor 1

1

0

Small-scale

0.251

Low

106336

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

505482

UCRIL
Putative cytochrome b-c1 complex subunit Rieske-like protein 1

1

0

High-throughput

0.249

Low

716206

ERP29
Endoplasmic reticulum resident protein 29

1

0

High-throughput

0.232

Low

1350957

SL9A8
Sodium/hydrogen exchanger 8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025