HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: DTX2 (Q86UW9)
Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2)
Gene: DTX2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.658

Property	Details
Experiments	32296183, 32937373, unassigned1304
Identification Methods	two hybrid, pull down, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0016567 - protein ubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 622
+	Hs
		1289342 UB2D4_HUMAN (1-147): 3.4e-83: 242: 93.20		DTX2_HUMAN (1-622): 0: 573: 100.00
+	Hs
		906692 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		DTX2_HUMAN (1-622): 0: 573: 100.00
+	Hs
		957122 UB2D3_HUMAN (1-147): 2.22e-81: 237: 97.28		DTX2_HUMAN (1-622): 0: 573: 100.00
+	Hs
		1294448 UB2D4_HUMAN (1-147): 3.4e-83: 242: 93.20		DTX1_HUMAN (17-616): 3.5e-168: 495: 45.85
+	Hs
		906697 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		DTX1_HUMAN (17-616): 3.5e-168: 495: 45.85
+	Hs
		982233 UB2D2_HUMAN (1-147): 1.58e-82: 240: 100.00		DTX1_HUMAN (17-616): 3.5e-168: 495: 45.85
+	Hs
		957126 UB2D3_HUMAN (1-147): 2.22e-81: 237: 97.28		DTX1_HUMAN (17-616): 3.5e-168: 495: 45.85
+	Hs
		909342 UB2E1_HUMAN (4-146): 1.76e-72: 216: 65.73		DTX1_HUMAN (17-616): 3.5e-168: 495: 45.85
+	Hs
		1350958 UB2D4_HUMAN (1-147): 3.4e-83: 242: 93.20		DTX3L_HUMAN (340-614): 2.86e-77: 262: 35.94
+	Hs
		906716 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		DTX3L_HUMAN (340-614): 2.86e-77: 262: 35.94
+	Hs
		982257 UB2D2_HUMAN (1-147): 1.58e-82: 240: 100.00		DTX3L_HUMAN (340-614): 2.86e-77: 262: 35.94
+	Hs
		957143 UB2D3_HUMAN (1-147): 2.22e-81: 237: 97.28		DTX3L_HUMAN (340-614): 2.86e-77: 262: 35.94
+	Hs
		1350942 UB2E2_HUMAN (4-146): 1.32e-74: 222: 65.73		DTX3L_HUMAN (340-614): 2.86e-77: 262: 35.94
+	Hs
		1350938 UB2E3_HUMAN (4-146): 5.71e-74: 221: 66.43		DTX3L_HUMAN (340-614): 2.86e-77: 262: 35.94
+	Hs
		1331925 UB2D4_HUMAN (1-147): 3.4e-83: 242: 93.20		DTX3_HUMAN (439-617): 3.98e-65: 219: 43.65
+	Hs
		906708 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		DTX3_HUMAN (439-617): 3.98e-65: 219: 43.65
+	Hs
		982247 UB2D2_HUMAN (1-147): 1.58e-82: 240: 100.00		DTX3_HUMAN (439-617): 3.98e-65: 219: 43.65
+	Hs
		957133 UB2D3_HUMAN (1-147): 2.22e-81: 237: 97.28		DTX3_HUMAN (439-617): 3.98e-65: 219: 43.65
+	Hs
		1331911 UB2E2_HUMAN (4-146): 1.32e-74: 222: 65.73		DTX3_HUMAN (439-617): 3.98e-65: 219: 43.65
+	Hs
		1331904 UB2E3_HUMAN (4-146): 5.71e-74: 221: 66.43		DTX3_HUMAN (439-617): 3.98e-65: 219: 43.65