HitPredict

Interactor 1: AGRIN (O00468)
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)]
Gene: AGRN

Interactor 2: EDN3 (P14138)
Endothelin-3 (ET-3) (Preproendothelin-3) (PPET3)
Gene: EDN3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0007165 - signal transduction
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 2068 Hs			1 238
+	Hs
		535622 NOTC1_HUMAN (1290-1921): 1.43e-30: 135: 14.16		EDN3_HUMAN (1-238): 3.65e-155: 431: 100.00
+	Hs
		535630 NOTC2_HUMAN (133-526): 6.63e-13: 76.7: 12.78		EDN3_HUMAN (1-238): 3.65e-155: 431: 100.00
+	Hs
		535627 PGBM_HUMAN (811-1102): 5.87e-10: 67.1: 16.67		EDN3_HUMAN (1-238): 3.65e-155: 431: 100.00
+	Hs
		535684 CELR1_HUMAN (1678-1906): 5.63e-09: 64: 14.11		EDN3_HUMAN (1-238): 3.65e-155: 431: 100.00