HitPredict

Interactor 1: YAF2 (Q8IY57)
YY1-associated factor 2
Gene: YAF2

Interactor 2: PCGF6 (Q9BYE7)
Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134)
Gene: PCGF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.945

Property	Details
Experiments	28514442, 27705803, 24981860, 33961781, 22325352, unassigned3799
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RAWUL~YAF2_RYBP
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 180 Hs			1 350
+	Hs
		765690 YAF2_HUMAN (1-180): 8.55e-73: 218: 100.00		BMI1_HUMAN (117-349): 4.01e-69: 221: 34.30
+	Hs
		766102 YAF2_HUMAN (1-180): 8.55e-73: 218: 100.00		PCGF2_HUMAN (117-350): 1.73e-63: 207: 33.47
+	Hs
		1185921 YAF2_HUMAN (1-180): 8.55e-73: 218: 100.00		PCGF3_HUMAN (120-341): 9.55e-64: 204: 34.44
+	Mm
		1298253 RYBP_MOUSE (1-179): 3.53e-49: 160: 49.78		PCGF6_MOUSE (41-350): 4.64e-83: 258: 92.90
+	Hs
		1314044 YAF2_HUMAN (1-180): 8.55e-73: 218: 100.00		PCGF1_HUMAN (119-347): 6.54e-59: 192: 35.35
+	Hs
		1286244 YAF2_HUMAN (1-180): 8.55e-73: 218: 100.00		PCGF5_HUMAN (117-344): 5.03e-49: 167: 31.73
+	Mm
		662907 RYBP_MOUSE (1-179): 3.53e-49: 160: 49.78		PCGF2_MOUSE (117-350): 3.73e-61: 201: 33.88
+	Dm
		1487165 Q9W215_DROME (1-133): 1.35e-51: 163: 51.13		Q9VV77_DROME (120-344): 1.88e-61: 197: 37.45
+	Mm
		1298250 RYBP_MOUSE (1-179): 3.53e-49: 160: 49.78		PCGF1_MOUSE (119-347): 9.33e-59: 192: 35.35
+	Dm
		777176 Q9W215_DROME (1-133): 1.35e-51: 163: 51.13		PSC_DROME (42-349): 4.5e-52: 187: 28.08
+	Mm
		1408843 YAF2_MOUSE (1-180): 3.81e-76: 227: 91.67		RING2_MOUSE (85-303): 2.32e-31: 122: 14.49
+	Hs
		1089230 YAF2_HUMAN (1-180): 8.55e-73: 218: 100.00		TRI26_HUMAN (121-315): 1.16e-30: 123: 19.90
+	Hs
		1314041 YAF2_HUMAN (1-180): 8.55e-73: 218: 100.00		RING2_HUMAN (85-303): 2.73e-31: 122: 14.49
+	Hs
		1055823 YAF2_HUMAN (1-180): 8.55e-73: 218: 100.00		RING1_HUMAN (109-211): 8.16e-25: 105: 25.96
+	Dm
		669805 Q9W215_DROME (1-133): 1.35e-51: 163: 51.13		SUZ2_DROME (101-344): 3.33e-39: 150: 20.80
+	Hs
		623443 RYBP_HUMAN (1-179): 5.82e-49: 160: 49.78		RO52_HUMAN (121-311): 1.2e-33: 131: 18.75
+	Mm
		1298254 RYBP_MOUSE (1-179): 3.53e-49: 160: 49.78		RING2_MOUSE (85-303): 2.32e-31: 122: 14.49
+	Hs
		302583 RYBP_HUMAN (1-179): 5.82e-49: 160: 49.78		RNF8_HUMAN (74-217): 5.99e-27: 112: 24.16
+	Dm
		1468841 Q9W215_DROME (1-133): 1.35e-51: 163: 51.13		RING1_DROME (108-243): 8.95e-26: 108: 22.63
+	Mm
		205495 RYBP_MOUSE (1-179): 3.53e-49: 160: 49.78		RING1_MOUSE (109-211): 5.14e-25: 106: 25.96