HitPredict

Interactor 1: PALS1 (Q8N3R9)
Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1)
Gene: PALS1

Interactor 2: LIN7C (Q9NUP9)
Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3)
Gene: LIN7C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.964

Property	Details
Experiments	26186194, 24366813, 28514442, 32296183, 33961781, unassigned3799, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, L27~L27, PDZ~PDZ, PDZ~SH3_2
Common GO terms	GO:0002011 - morphogenesis of an epithelial sheet GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005923 - bicellular tight junction GO:0019904 - protein domain specific binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 675 Hs			1 197
+	Mm
		313209 PALS1_MOUSE (1-675): 0: 579: 96.74		LIN7C_MOUSE (1-197): 1.56e-57: 181: 100.00
+	Hs
		1325312 PALS1_HUMAN (1-675): 0: 581: 100.00		LIN7B_HUMAN (1-196): 1.24e-54: 174: 84.69
+	Hs
		167711 PALS1_HUMAN (1-675): 0: 581: 100.00		LIN7A_HUMAN (6-194): 6.41e-51: 165: 80.42
+	Hs
		1325323 PALS1_HUMAN (1-675): 0: 581: 100.00		SNTG2_HUMAN (26-188): 2.96e-32: 123: 25.46
+	Hs
		1325304 PALS1_HUMAN (1-675): 0: 581: 100.00		MPP4_HUMAN (12-174): 9.77e-31: 119: 26.99
+	Hs
		299772 PALS1_HUMAN (1-675): 0: 581: 100.00		MPDZ_HUMAN (42-162): 2.32e-12: 66.7: 20.66
+	Hs
		1325295 PALS1_HUMAN (1-675): 0: 581: 100.00		INADL_HUMAN (112-194): 7.91e-11: 62.5: 28.24
+	Hs
		1325307 PALS1_HUMAN (1-675): 0: 581: 100.00		MAGI1_HUMAN (94-172): 5.43e-10: 60.1: 35.44
+	Dm
		122386 M9PJD0_DROME (227-674): 2.36e-146: 469: 50.83		Q9VBY7_DROME (1-195): 2.79e-52: 168: 80.00
+	Hs
		1450016 PALS2_HUMAN (134-674): 1.15e-145: 436: 34.48		LIN7C_HUMAN (1-197): 1.56e-57: 181: 100.00
+	Hs
		168758 CSKP_HUMAN (9-674): 5.27e-140: 434: 25.94		LIN7C_HUMAN (1-197): 1.56e-57: 181: 100.00
+	Hs
		1437597 PALS2_HUMAN (134-674): 1.15e-145: 436: 34.48		LIN7B_HUMAN (1-196): 1.24e-54: 174: 84.69
+	Hs
		168750 CSKP_HUMAN (9-674): 5.27e-140: 434: 25.94		LIN7B_HUMAN (1-196): 1.24e-54: 174: 84.69
+	Hs
		167723 PALS2_HUMAN (134-674): 1.15e-145: 436: 34.48		LIN7A_HUMAN (6-194): 6.41e-51: 165: 80.42
+	Hs
		167670 CSKP_HUMAN (9-674): 5.27e-140: 434: 25.94		LIN7A_HUMAN (6-194): 6.41e-51: 165: 80.42
+	Hs
		168683 CSKP_HUMAN (9-674): 5.27e-140: 434: 25.94		SNTB2_HUMAN (61-179): 3.01e-32: 123: 35.25
+	Hs
		168585 CSKP_HUMAN (9-674): 5.27e-140: 434: 25.94		CSKP_HUMAN (13-194): 7.06e-31: 120: 20.53
+	Hs
		168670 CSKP_HUMAN (9-674): 5.27e-140: 434: 25.94		DLG4_HUMAN (14-196): 4.48e-23: 97.9: 22.87
+	Hs
		168680 CSKP_HUMAN (9-674): 5.27e-140: 434: 25.94		DLG1_HUMAN (50-178): 6.75e-23: 97.1: 30.60
+	Hs
		168730 CSKP_HUMAN (9-674): 5.27e-140: 434: 25.94		DLG3_HUMAN (74-164): 8.63e-20: 88.3: 35.42