HitPredict

Interactor 1: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Interactor 2: TNIK (Q9UKE5)
TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)
Gene: TNIK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Pkinase
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 779 Hs			1 1360
+	Hs
		1233543 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		MINK1_HUMAN (1-1360): 0: 1051: 60.43
+	Hs
		324878 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		M4K4_HUMAN (1-1360): 0: 970: 59.11
+	Hs
		1263851 CNKR2_HUMAN (1-468): 1.39e-46: 181: 13.77		TNIK_HUMAN (1-1360): 0: 1235: 100.00
+	Mm
		949351 CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40		TNIK_MOUSE (1-1360): 0: 1208: 96.10
+	Mm
		1194491 CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40		MINK1_MOUSE (1-1360): 0: 1066: 62.01
+	Hs
		1137906 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		MRCKA_HUMAN (12-1330): 0: 690: 13.75
+	Hs
		324737 RASA1_HUMAN (72-437): 2.74e-44: 174: 11.32		M4K4_HUMAN (1-1360): 0: 970: 59.11
+	Hs
		1331749 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		MRCKB_HUMAN (15-1330): 0: 661: 15.04
+	Hs
		850712 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		KS6A3_HUMAN (10-709): 1.25e-135: 435: 16.74
+	Hs
		647959 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		MARK3_HUMAN (3-675): 1.72e-124: 406: 16.37
+	Hs
		682210 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		AKT2_HUMAN (3-352): 5.78e-123: 392: 22.87
+	Hs
		1023113 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		STK4_HUMAN (5-482): 7.72e-121: 387: 33.06
+	Hs
		1027433 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		STK3_HUMAN (4-485): 1.79e-115: 372: 29.28
+	Hs
		131607 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		STK25_HUMAN (20-410): 8.77e-113: 362: 37.91
+	Hs
		1331504 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		STK26_HUMAN (16-400): 7.78e-113: 362: 38.27
+	Hs
		1331766 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		STK24_HUMAN (20-340): 2.15e-111: 359: 43.03
+	Hs
		1073480 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		KS6A1_HUMAN (2-350): 9.65e-97: 329: 22.63
+	Hs
		1331724 PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00		M4K5_HUMAN (19-373): 7.89e-73: 263: 40.38
+	Mm
		1169650 CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40		TAOK2_MOUSE (1-858): 2.53e-132: 440: 22.14
+	Sc
		419871 OSH3_YEAST (21-718): 7.21e-65: 235: 11.98		SNF1_YEAST (23-474): 8.57e-108: 356: 22.34