HitPredict

Interactor 1: Q8NEX1 (Q8NEX1)
E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)
Gene: Q8NEX1

Interactor 2: UB2D4 (Q9Y2X8)
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)
Gene: UBE2D4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.80	0.528

Property	Details
Experiments	19690564
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 180 Hs			1 147
+	Hs
		906710 Q8NEX1_HUMAN (1-180): 7.75e-64: 196: 100.00		UB2D1_HUMAN (1-147): 3.33e-83: 242: 91.84
+	Hs
		982251 Q8NEX1_HUMAN (1-180): 7.75e-64: 196: 100.00		UB2D2_HUMAN (1-147): 7.67e-83: 241: 93.20
+	Hs
		957137 Q8NEX1_HUMAN (1-180): 7.75e-64: 196: 100.00		UB2D3_HUMAN (1-147): 8.57e-82: 238: 91.84
+	Hs
		1340074 ZNRF2_HUMAN (21-180): 1.37e-53: 172: 100.00		UB2D4_HUMAN (1-147): 4.38e-84: 244: 100.00
+	Hs
		906711 ZNRF2_HUMAN (21-180): 1.37e-53: 172: 100.00		UB2D1_HUMAN (1-147): 3.33e-83: 242: 91.84
+	Hs
		982253 ZNRF2_HUMAN (21-180): 1.37e-53: 172: 100.00		UB2D2_HUMAN (1-147): 7.67e-83: 241: 93.20
+	Hs
		957140 ZNRF2_HUMAN (21-180): 1.37e-53: 172: 100.00		UB2D3_HUMAN (1-147): 8.57e-82: 238: 91.84
+	Hs
		957795 Q8NEX1_HUMAN (1-180): 7.75e-64: 196: 100.00		UBE2N_HUMAN (4-147): 2.31e-69: 207: 46.53
+	Hs
		1340067 ZNRF2_HUMAN (21-180): 1.37e-53: 172: 100.00		UB2E2_HUMAN (4-146): 2.83e-75: 224: 64.34
+	Hs
		1340065 ZNRF2_HUMAN (21-180): 1.37e-53: 172: 100.00		UB2E3_HUMAN (4-146): 1.06e-74: 223: 64.34
+	Hs
		906709 ZNRF1_HUMAN (12-180): 1.28e-45: 151: 49.46		UB2D1_HUMAN (1-147): 3.33e-83: 242: 91.84
+	Hs
		982250 ZNRF1_HUMAN (12-180): 1.28e-45: 151: 49.46		UB2D2_HUMAN (1-147): 7.67e-83: 241: 93.20
+	Hs
		909354 ZNRF2_HUMAN (21-180): 1.37e-53: 172: 100.00		UB2E1_HUMAN (4-146): 3.9e-73: 218: 64.34
+	Hs
		957136 ZNRF1_HUMAN (12-180): 1.28e-45: 151: 49.46		UB2D3_HUMAN (1-147): 8.57e-82: 238: 91.84
+	Hs
		957796 ZNRF2_HUMAN (21-180): 1.37e-53: 172: 100.00		UBE2N_HUMAN (4-147): 2.31e-69: 207: 46.53
+	Hs
		1336242 ZNRF1_HUMAN (12-180): 1.28e-45: 151: 49.46		UB2E2_HUMAN (4-146): 2.83e-75: 224: 64.34
+	Hs
		1336239 ZNRF1_HUMAN (12-180): 1.28e-45: 151: 49.46		UB2E3_HUMAN (4-146): 1.06e-74: 223: 64.34
+	Hs
		909353 ZNRF1_HUMAN (12-180): 1.28e-45: 151: 49.46		UB2E1_HUMAN (4-146): 3.9e-73: 218: 64.34
+	Hs
		957793 ZNRF1_HUMAN (12-180): 1.28e-45: 151: 49.46		UBE2N_HUMAN (4-147): 2.31e-69: 207: 46.53
+	Zm
		35978 B4FHZ7_MAIZE (20-178): 8.61e-47: 157: 21.74		A0A1D6LTJ2_MAIZE (1-112): 1.24e-60: 186: 76.79