Protein: ZNRF2
E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)

Gene: ZNRF2
Organism: Homo sapiens
Interactions: 45
UniProt ID: Q8NHG8

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005765 - lysosomal membrane
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

957796

UBE2N
Ubiquitin-conjugating enzyme E2 N

6

20

Small-scale

0.946

High

906711

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

20

Small-scale

0.754

High

909354

UB2E1
Ubiquitin-conjugating enzyme E2 E1

2

20

Small-scale

0.754

High

957140

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.754

High

982253

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

20

Small-scale

0.754

High

508304

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

Small-scale

0.647

High

691264

1433T
14-3-3 protein theta

2

3

Small-scale

0.624

High

1103920

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

20

Small-scale

0.621

High

1340065

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

Small-scale

0.621

High

1340066

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

19

Small-scale

0.621

High

1340067

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

20

Small-scale

0.621

High

1340071

AKTIP
AKT-interacting protein

1

18

Small-scale

0.621

High

1340072

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

20

Small-scale

0.621

High

1340074

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.621

High

1336236

ZNRF1
E3 ubiquitin-protein ligase ZNRF1

1

1

Small-scale

0.618

High

177268

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

2

2

Small-scale

0.611

High

1334469

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.586

High

143667

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

0

Small-scale

0.537

High

839322

MTOR
Serine/threonine-protein kinase mTOR

1

0

Small-scale

0.537

High

273694

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

2

High-throughput

0.536

High

966645

1433G
14-3-3 protein gamma

1

3

High-throughput

0.536

High

1049584

1433F
14-3-3 protein eta

1

3

High-throughput

0.536

High

1141800

EEA1
Early endosome antigen 1

1

1

High-throughput

0.536

High

1340073

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

2

High-throughput

0.536

High

535947

MYH3
Myosin-3

1

0

High-throughput

0.513

High

1244732

KLD10
Kelch domain-containing protein 10

1

0

High-throughput

0.513

High

1340064

ARHG2
Rho guanine nucleotide exchange factor 2

1

0

High-throughput

0.513

High

1340069

ABCA2
ATP-binding cassette sub-family A member 2

1

0

High-throughput

0.513

High

1340076

TLN1
Talin-1

1

0

High-throughput

0.513

High

420627

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

3

Small-scale

0.501

High

66720

CGB1
Choriogonadotropin subunit beta variant 1

1

0

High-throughput

0.493

High

229239

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

0

High-throughput

0.493

High

1331005

ANR44
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

1

2

High-throughput

0.489

High

1333059

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

1

2

High-throughput

0.489

High

899669

AT1A2
Sodium/potassium-transporting ATPase subunit alpha-2

1

3

Small-scale

0.479

High

1204770

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

2

Small-scale

0.479

High

1322595

RPTOR
Regulatory-associated protein of mTOR

1

1

Small-scale

0.479

High

1340068

LST8
Target of rapamycin complex subunit LST8

1

1

Small-scale

0.479

High

173104

XPO1
Exportin-1

1

0

High-throughput

0.458

High

1233368

LTOR1
Ragulator complex protein LAMTOR1

1

0

Small-scale

0.458

High

1340070

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

1340075

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

0

Small-scale

0.458

High

1291933

WDR5B
WD repeat-containing protein 5B

2

0

High-throughput

0.328

High

155207

NCKP5
Nck-associated protein 5

1

0

High-throughput

0.279

Low

1326713

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025