HitPredict

Interactor 1: Q8WWE8 (Q8WWE8)
CYTH4 protein
Gene: CYTH4

Interactor 2: CNKR1 (Q969H4)
Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like)
Gene: CNKSR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.80	0.594

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Sec7
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 118 Hs			1 720
+	Hs
		1380312 CYH4_HUMAN (1-118): 1.52e-45: 153: 100.00		CNKR1_HUMAN (1-720): 0: 554: 100.00
+	Hs
		1380307 CYH2_HUMAN (7-118): 9.06e-42: 143: 49.11		CNKR1_HUMAN (1-720): 0: 554: 100.00
+	Hs
		1149057 CYH1_HUMAN (8-118): 6.33e-41: 140: 56.76		CNKR1_HUMAN (1-720): 0: 554: 100.00
+	Hs
		225488 CYH3_HUMAN (22-118): 7.41e-36: 127: 57.73		CNKR1_HUMAN (1-720): 0: 554: 100.00
+	Mm
		989415 CYH2_MOUSE (7-118): 4.9e-42: 144: 50.00		CNKR2_MOUSE (337-719): 1.04e-59: 219: 22.86
+	Mm
		1282988 CYH1_MOUSE (8-118): 9.3e-42: 143: 55.86		CNKR2_MOUSE (337-719): 1.04e-59: 219: 22.86
+	Mm
		148524 CYH3_MOUSE (22-118): 7.69e-36: 127: 57.73		CNKR2_MOUSE (337-719): 1.04e-59: 219: 22.86
+	Hs
		225479 CYH1_HUMAN (8-118): 6.33e-41: 140: 56.76		CYH3_HUMAN (165-516): 1.41e-58: 205: 13.00
+	Hs
		1149061 CYH2_HUMAN (7-118): 9.06e-42: 143: 49.11		CYH1_HUMAN (142-521): 2.85e-52: 187: 12.56
+	Mm
		1282979 IQEC1_MOUSE (51-118): 2.96e-24: 97.8: 35.29		CNKR2_MOUSE (337-719): 1.04e-59: 219: 22.86
+	Dm
		1466806 Q9V9Q6_DROME (9-118): 2.18e-39: 137: 48.18		Q9V9Q6_DROME (150-521): 1.13e-43: 164: 13.35
+	Hs
		1359656 CYH4_HUMAN (1-118): 1.52e-45: 153: 100.00		ICEF1_HUMAN (569-704): 3.3e-25: 111: 32.35
+	Hs
		1359655 CYH2_HUMAN (7-118): 9.06e-42: 143: 49.11		ICEF1_HUMAN (569-704): 3.3e-25: 111: 32.35
+	Hs
		1149055 CYH1_HUMAN (8-118): 6.33e-41: 140: 56.76		ICEF1_HUMAN (569-704): 3.3e-25: 111: 32.35
+	Hs
		225486 CYH3_HUMAN (22-118): 7.41e-36: 127: 57.73		ICEF1_HUMAN (569-704): 3.3e-25: 111: 32.35
+	Dm
		1268535 Q9V9Q6_DROME (9-118): 2.18e-39: 137: 48.18		Q7KNQ9_DROME (244-601): 6.38e-21: 100: 18.38
+	Hs
		1434369 BIG1_HUMAN (7-117): 1.01e-30: 116: 27.43		PKHA4_HUMAN (383-502): 1.22e-26: 118: 26.40
+	Hs
		1434368 BIG2_HUMAN (11-117): 6.92e-30: 114: 23.08		PKHA4_HUMAN (383-502): 1.22e-26: 118: 26.40