HitPredict

Interactor 1: PRDX1 (Q06830)
Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1)
Gene: PRDX1

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	36199071, 21988832
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 199 Hs			1 605
+	Hs
		685797 PRDX2_HUMAN (1-198): 2.38e-103: 297: 77.78		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		670992 PRDX3_HUMAN (2-197): 1.85e-98: 287: 62.76		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Mm
		139713 PRDX6_MOUSE (4-197): 1.21e-68: 210: 29.47		FBXW7_MOUSE (76-527): 2.98e-83: 277: 23.71
+	Hs
		1026714 PRDX4_HUMAN (4-197): 4.03e-95: 279: 69.59		WDR5B_HUMAN (409-604): 7.04e-48: 172: 29.27
+	Hs
		903161 PRDX1_HUMAN (1-199): 2.21e-105: 302: 100.00		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Hs
		1026733 PRDX4_HUMAN (4-197): 4.03e-95: 279: 69.59		POC1B_HUMAN (189-438): 4.67e-35: 140: 13.27
+	Hs
		670686 PRDX6_HUMAN (4-197): 5.84e-67: 206: 28.50		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33