HitPredict

Interactor 1: SOCS4 (Q8WXH5)
Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7)
Gene: SOCS4

Interactor 2: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	28514442, 31253590, 33961781, 21145461
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 440 Hs			1 780
+	Mm
		1362447 SOCS4_MOUSE (1-439): 4.7e-168: 480: 86.79		CUL5_MOUSE (1-780): 0: 785: 98.46
+	Hs
		273313 SOCS5_HUMAN (7-436): 1.82e-134: 398: 52.72		CUL5_HUMAN (1-780): 0: 791: 100.00
+	Mm
		236703 SOCS5_MOUSE (7-436): 1.24e-130: 389: 52.26		CUL5_MOUSE (1-780): 0: 785: 98.46
+	Hs
		1371879 CISH_HUMAN (212-425): 5.47e-51: 174: 22.93		CUL5_HUMAN (1-780): 0: 791: 100.00
+	Hs
		155125 SOCS2_HUMAN (234-425): 1.65e-46: 160: 25.85		CUL5_HUMAN (1-780): 0: 791: 100.00
+	Hs
		193297 SOCS1_HUMAN (260-425): 3.01e-46: 160: 22.29		CUL5_HUMAN (1-780): 0: 791: 100.00
+	Hs
		156064 SOCS6_HUMAN (220-424): 7.37e-41: 154: 29.22		CUL5_HUMAN (1-780): 0: 791: 100.00
+	Hs
		155175 SOCS7_HUMAN (209-439): 3.54e-40: 153: 22.76		CUL5_HUMAN (1-780): 0: 791: 100.00
+	Mm
		205438 SOCS1_MOUSE (260-425): 6.64e-46: 159: 22.29		CUL5_MOUSE (1-780): 0: 785: 98.46
+	Mm
		205447 SOCS2_MOUSE (234-425): 2.85e-45: 157: 26.34		CUL5_MOUSE (1-780): 0: 785: 98.46
+	Mm
		1354086 SOCS7_MOUSE (209-439): 1.73e-40: 154: 22.76		CUL5_MOUSE (1-780): 0: 785: 98.46
+	Mm
		1424095 SOCS6_MOUSE (220-424): 1.54e-40: 153: 29.68		CUL5_MOUSE (1-780): 0: 785: 98.46
+	Mm
		1223902 CISH_MOUSE (211-425): 2.38e-40: 146: 23.32		CUL5_MOUSE (1-780): 0: 785: 98.46
+	Hs
		1114412 CISH_HUMAN (212-425): 5.47e-51: 174: 22.93		CUL3_HUMAN (8-780): 0: 753: 22.96
+	Mm
		205475 SOCS3_MOUSE (250-422): 8.03e-39: 141: 20.09		CUL5_MOUSE (1-780): 0: 785: 98.46
+	Hs
		1113357 SHE_HUMAN (165-384): 1.26e-47: 172: 12.61		CUL3_HUMAN (8-780): 0: 753: 22.96
+	Hs
		440067 LCK_HUMAN (184-418): 4.67e-42: 157: 15.57		CUL3_HUMAN (8-780): 0: 753: 22.96
+	Hs
		155108 SOCS2_HUMAN (234-425): 1.65e-46: 160: 25.85		CUL4A_HUMAN (16-780): 0: 743: 24.48
+	Hs
		1112999 CISH_HUMAN (212-425): 5.47e-51: 174: 22.93		CUL2_HUMAN (6-780): 0: 697: 26.36
+	Hs
		193268 SOCS1_HUMAN (260-425): 3.01e-46: 160: 22.29		CUL2_HUMAN (6-780): 0: 697: 26.36