Protein: SOCS2
Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)

Gene: SOCS2
Organism: Homo sapiens
Interactions: 94
UniProt ID: O14508

Gene Ontology (top 5):
GO:0001558 - regulation of cell growth
GO:0005126 - cytokine receptor binding
GO:0005131 - growth hormone receptor binding
GO:0005159 - insulin-like growth factor receptor binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

155125

CUL5
Cullin-5

12

20

Small-scale

0.981

High

155113

ELOC
Elongin-C

7

10

Small-scale

0.960

High

155069

GHR
Growth hormone receptor

6

20

Small-scale

0.937

High

155075

EPOR
Erythropoietin receptor

4

20

Small-scale

0.898

High

155066

IGF1R
Insulin-like growth factor 1 receptor

2

20

Small-scale

0.815

High

155065

YES
Tyrosine-protein kinase Yes

2

20

High-throughput

0.783

High

155053

SOCS1
Suppressor of cytokine signaling 1

2

18

Small-scale

0.754

High

155114

ELOB
Elongin-B

6

11

Small-scale

0.722

High

155110

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.713

High

155068

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

155090

CRK
Adapter molecule crk

1

20

High-throughput

0.665

High

155092

STA5B
Signal transducer and activator of transcription 5B

1

20

High-throughput

0.665

High

155060

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.647

High

155076

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

155112

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

155105

FAK1
Focal adhesion kinase 1

1

20

High-throughput

0.621

High

155067

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.619

High

155048

SOCS3
Suppressor of cytokine signaling 3

1

19

Small-scale

0.618

High

155062

NTRK1
High affinity nerve growth factor receptor

1

20

Small-scale

0.618

High

155063

LCK
Tyrosine-protein kinase Lck

1

20

Small-scale

0.618

High

155074

IL7RA
Interleukin-7 receptor subunit alpha

1

4

Small-scale

0.618

High

155081

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

Small-scale

0.618

High

155086

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

20

Small-scale

0.618

High

155088

MTOR
Serine/threonine-protein kinase mTOR

1

12

Small-scale

0.618

High

155108

CUL4A
Cullin-4A

1

20

High-throughput

0.618

High

155115

NTRK2
BDNF/NT-3 growth factors receptor

1

20

Small-scale

0.618

High

155133

RBX2
RING-box protein 2

2

12

Small-scale

0.611

High

155058

STK16
Serine/threonine-protein kinase 16

2

14

High-throughput

0.606

High

155129

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

2

6

High-throughput

0.601

High

155080

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.595

High

155118

CACL1
CDK2-associated and cullin domain-containing protein 1

1

20

High-throughput

0.595

High

155083

BMI1
Polycomb complex protein BMI-1

1

10

High-throughput

0.541

High

155077

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.527

High

155093

JAK3
Tyrosine-protein kinase JAK3

1

20

Small-scale

0.527

High

155061

PA21B
Phospholipase A2

1

0

High-throughput

0.518

High

123009

DX39A
ATP-dependent RNA helicase DDX39A

1

5

High-throughput

0.515

High

128100

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

2

High-throughput

0.515

High

155049

IRS4
Insulin receptor substrate 4

1

20

High-throughput

0.515

High

155051

BACH1
Transcription regulator protein BACH1

1

5

High-throughput

0.515

High

155055

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

20

High-throughput

0.515

High

155059

IPO7
Importin-7

1

3

High-throughput

0.515

High

155072

EZRI
Ezrin

1

20

High-throughput

0.515

High

155082

CTNB1
Catenin beta-1

1

11

High-throughput

0.515

High

155094

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

High-throughput

0.515

High

155098

CSN2
COP9 signalosome complex subunit 2

1

2

High-throughput

0.515

High

155100

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.515

High

155101

RAB1A
Ras-related protein Rab-1A

1

6

High-throughput

0.515

High

155102

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

2

High-throughput

0.515

High

155106

EF1A2
Elongation factor 1-alpha 2

1

3

High-throughput

0.515

High

155109

TTL12
Tubulin--tyrosine ligase-like protein 12

1

1

High-throughput

0.515

High

155121

WDTC1
WD and tetratricopeptide repeats protein 1

1

11

High-throughput

0.515

High

155124

RBP56
TATA-binding protein-associated factor 2N

1

5

High-throughput

0.515

High

155127

DCNL5
DCN1-like protein 5

1

3

High-throughput

0.515

High

155128

NADAP
Kanadaptin

1

3

High-throughput

0.515

High

155136

CSN3
COP9 signalosome complex subunit 3

1

2

High-throughput

0.515

High

155138

RRP44
Exosome complex exonuclease RRP44

1

1

High-throughput

0.515

High

155087

VHL
von Hippel-Lindau disease tumor suppressor

1

2

High-throughput

0.515

High

155117

HIKES
Protein Hikeshi

1

0

High-throughput

0.513

High

155052

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.493

High

155054

OGA
Protein O-GlcNAcase

1

0

High-throughput

0.493

High

155064

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.493

High

155071

GLNA
Glutamine synthetase

1

0

High-throughput

0.493

High

155084

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

0

High-throughput

0.493

High

155085

VATE1
V-type proton ATPase subunit E 1

1

0

High-throughput

0.493

High

155091

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

0

High-throughput

0.493

High

155123

KNL1
Outer kinetochore KNL1 complex subunit KNL1

1

0

High-throughput

0.493

High

155095

ARFP2
Arfaptin-2

1

2

High-throughput

0.481

High

155096

TPD52
Tumor protein D52

1

2

High-throughput

0.481

High

155120

RYBP
RING1 and YY1-binding protein

1

1

Small-scale

0.481

High

155073

PRLR
Prolactin receptor

1

20

Small-scale

0.479

High

155107

SQSTM
Sequestosome-1

1

4

Small-scale

0.479

High

155111

STK38
Serine/threonine-protein kinase 38

1

20

Small-scale

0.479

High

155119

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

20

Small-scale

0.479

High

155130

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

5

Small-scale

0.479

High

155050

SCAM3
Secretory carrier-associated membrane protein 3

1

3

High-throughput

0.470

High

155057

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.470

High

155070

ADT3
ADP/ATP translocase 3

1

3

High-throughput

0.470

High

155079

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

5

High-throughput

0.470

High

155104

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

11

High-throughput

0.470

High

155116

SHRM1
Protein Shroom1

1

3

High-throughput

0.470

High

155126

KCD12
BTB/POZ domain-containing protein KCTD12

1

8

High-throughput

0.470

High

155131

GCP60
Golgi resident protein GCP60

1

1

High-throughput

0.470

High

155132

RTN4
Reticulon-4

1

5

High-throughput

0.470

High

155134

DIC
Mitochondrial dicarboxylate carrier

1

9

High-throughput

0.470

High

155135

NWD2
NACHT and WD repeat domain-containing protein 2

1

5

High-throughput

0.470

High

155139

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

1

High-throughput

0.470

High

155056

H2AY
Core histone macro-H2A.1

1

3

Small-scale

0.437

High

155078

CCNC
Cyclin-C

1

8

Small-scale

0.437

High

155137

XCT
Cystine/glutamate transporter

1

9

Small-scale

0.437

High

155089

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.269

Low

155099

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

0

High-throughput

0.269

Low

155103

SPT4H
Transcription elongation factor SPT4

1

0

High-throughput

0.269

Low

155122

UBAC2
Ubiquitin-associated domain-containing protein 2

1

0

High-throughput

0.269

Low

155097

CTBP2
C-terminal-binding protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025