Protein: SOCS3
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10)

Gene: SOCS3
Organism: Mus musculus
Interactions: 32
UniProt ID: O35718

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0005829 - cytosol
GO:0007165 - signal transduction
GO:0009898 - cytoplasmic side of plasma membrane
GO:0009968 - negative regulation of signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

205458

STAT3
Signal transducer and activator of transcription 3

7

20

Small-scale

0.951

High

205464

ELOC
Elongin-C

3

10

Small-scale

0.873

High

205465

IL6RB
Interleukin-6 receptor subunit beta

3

20

Small-scale

0.853

High

205468

JAK2
Tyrosine-protein kinase JAK2

2

20

Small-scale

0.799

High

205463

ELOB
Elongin-B

3

11

Small-scale

0.681

High

205475

CUL5
Cullin-5

3

20

Small-scale

0.664

High

73018

B1ASP2
Tyrosine-protein kinase

1

20

Small-scale

0.647

High

205457

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

Small-scale

0.625

High

205453

EPOR
Erythropoietin receptor

1

20

Small-scale

0.618

High

205456

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.618

High

205459

CRKL
Crk-like protein

1

20

Small-scale

0.618

High

205462

STAT6
Signal transducer and transcription activator 6

1

20

Small-scale

0.618

High

205473

NCK1
SH2/SH3 adapter protein Nck1

1

20

Small-scale

0.618

High

205460

LEPR
Leptin receptor

1

20

Small-scale

0.590

High

205455

I23O1
Indoleamine 2,3-dioxygenase 1

1

0

Small-scale

0.554

High

205454

INSR
Insulin receptor

1

20

Small-scale

0.553

High

205477

RBX2
RING-box protein 2

1

10

Small-scale

0.536

High

205478

BCL10
B-cell lymphoma/leukemia 10

1

0

Small-scale

0.493

High

205466

TFDP1
Transcription factor Dp-1

1

2

Small-scale

0.479

High

205467

RUNX2
Runt-related transcription factor 2

1

6

Small-scale

0.479

High

205469

Q80SY9
Nucleotide-binding oligomerization domain-containing protein 2

1

2

Small-scale

0.479

High

205470

SMAD3
Mothers against decapentaplegic homolog 3

1

6

Small-scale

0.479

High

205471

MAP1S
Microtubule-associated protein 1S

1

5

Small-scale

0.479

High

205476

KC1E
Casein kinase I isoform epsilon

1

9

Small-scale

0.479

High

205448

CSN5
COP9 signalosome complex subunit 5

1

0

Small-scale

0.458

High

205472

CSN8
COP9 signalosome complex subunit 8

1

0

Small-scale

0.458

High

205474

CSN7A
COP9 signalosome complex subunit 7a

1

0

Small-scale

0.458

High

205449

CSN4
COP9 signalosome complex subunit 4

1

1

Small-scale

0.437

High

205450

CSN6
COP9 signalosome complex subunit 6

1

1

Small-scale

0.437

High

205451

CASK
Kappa-casein

1

1

Small-scale

0.437

High

205452

CASB
Beta-casein

1

1

Small-scale

0.437

High

205461

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

1

Small-scale

0.437

High


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Last updated: 11Aug2025