HitPredict

Interactor 1: CUL5 (Q9D5V5)
Cullin-5 (CUL-5)
Gene: CUL5

Interactor 2: SOCS6 (Q9JLY0)
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
Gene: SOCS6

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19385048
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Mm			1 533
+	Hs
		156064 CUL5_HUMAN (1-780): 0: 785: 98.46		SOCS6_HUMAN (1-533): 0: 634: 84.39
+	Mm
		1362447 CUL5_MOUSE (1-780): 0: 787: 100.00		SOCS4_MOUSE (367-533): 1.81e-52: 186: 36.91
+	Mm
		236703 CUL5_MOUSE (1-780): 0: 787: 100.00		SOCS5_MOUSE (367-533): 1.04e-51: 186: 36.31
+	Hs
		273313 CUL5_HUMAN (1-780): 0: 785: 98.46		SOCS5_HUMAN (367-533): 5.48e-52: 187: 36.31
+	Hs
		1360860 CUL5_HUMAN (1-780): 0: 785: 98.46		SOCS4_HUMAN (367-533): 5.45e-52: 184: 36.91
+	Mm
		205447 CUL5_MOUSE (1-780): 0: 787: 100.00		SOCS2_MOUSE (337-533): 3.99e-53: 180: 29.56
+	Mm
		1354086 CUL5_MOUSE (1-780): 0: 787: 100.00		SOCS7_MOUSE (368-533): 1.63e-46: 173: 53.57
+	Hs
		155175 CUL5_HUMAN (1-780): 0: 785: 98.46		SOCS7_HUMAN (368-533): 2.44e-46: 172: 53.57
+	Mm
		1223902 CUL5_MOUSE (1-780): 0: 787: 100.00		CISH_MOUSE (319-533): 2.27e-44: 159: 25.52
+	Hs
		155125 CUL5_HUMAN (1-780): 0: 785: 98.46		SOCS2_HUMAN (342-533): 1.29e-44: 158: 30.81
+	Hs
		1371879 CUL5_HUMAN (1-780): 0: 785: 98.46		CISH_HUMAN (329-533): 2.64e-43: 156: 26.27
+	Hs
		193297 CUL5_HUMAN (1-780): 0: 785: 98.46		SOCS1_HUMAN (377-533): 1.33e-41: 150: 26.75
+	Mm
		205438 CUL5_MOUSE (1-780): 0: 787: 100.00		SOCS1_MOUSE (377-533): 4.62e-41: 148: 26.75
+	Hs
		440067 CUL3_HUMAN (8-780): 0: 746: 22.71		LCK_HUMAN (260-493): 9.98e-53: 188: 17.21
+	Mm
		205475 CUL5_MOUSE (1-780): 0: 787: 100.00		SOCS3_MOUSE (349-531): 1.36e-38: 142: 24.89
+	Hs
		1114624 CUL3_HUMAN (8-780): 0: 746: 22.71		VAV3_HUMAN (235-482): 3.9e-48: 180: 20.76
+	Hs
		155960 CUL5_HUMAN (1-780): 0: 785: 98.46		SOCS3_HUMAN (349-531): 2.08e-37: 139: 25.81
+	Hs
		1114412 CUL3_HUMAN (8-780): 0: 746: 22.71		CISH_HUMAN (329-533): 2.64e-43: 156: 26.27
+	Hs
		136386 CUL3_HUMAN (8-780): 0: 746: 22.71		P85B_HUMAN (378-489): 1.33e-14: 78.6: 27.68
+	Hs
		699738 CUL3_HUMAN (8-780): 0: 746: 22.71		P85A_HUMAN (382-494): 6.55e-13: 73.6: 23.89