Protein: TF2H4
General transcription factor IIH subunit 4 (Basic transcription factor 2 52 kDa subunit) (BTF2 p52) (General transcription factor IIH polypeptide 4) (TFIIH basal transcription factor complex p52 subunit)

Gene: TF2H4, GTF2H4
Organism: Homo sapiens
Interactions: 66
UniProt ID: Q92759

Gene Ontology (top 5):
GO:0000438 - core TFIIH complex portion of holo TFIIH complex
GO:0000439 - transcription factor TFIIH core complex
GO:0001671 - ATPase activator activity
GO:0003690 - double-stranded DNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1173528

TF2H5
General transcription factor IIH subunit 5

8

1

Small-scale

0.972

High

584626

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

9

3

Small-scale

0.971

High

1046821

TF2H3
General transcription factor IIH subunit 3

5

2

Small-scale

0.931

High

841284

CDK7
Cyclin-dependent kinase 7

8

3

High-throughput

0.751

High

1046798

TF2H2
General transcription factor IIH subunit 2

7

3

Small-scale

0.743

High

697760

TF2H1
General transcription factor IIH subunit 1

4

2

Small-scale

0.689

High

1158419

T2H2L
General transcription factor IIH subunit 2-like protein

3

3

High-throughput

0.667

High

1270282

EAF1
ELL-associated factor 1

2

1

High-throughput

0.606

High

722626

T2FA
General transcription factor IIF subunit 1

2

0

Small-scale

0.592

High

1238569

EIF1A
Probable RNA-binding protein EIF1AD

2

0

High-throughput

0.580

High

589900

TBP
TATA-box-binding protein

1

1

Small-scale

0.550

High

664029

T2EA
General transcription factor IIE subunit 1

1

1

Small-scale

0.550

High

959962

TF2B
Transcription initiation factor IIB

1

1

Small-scale

0.550

High

370132

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

851272

MAT1
CDK-activating kinase assembly factor MAT1

1

2

High-throughput

0.536

High

624976

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.527

High

1067078

BRD3
Bromodomain-containing protein 3

1

2

High-throughput

0.515

High

125911

CDC7
Cell division cycle 7-related protein kinase

1

0

High-throughput

0.513

High

617619

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.513

High

659936

ERCC5
DNA excision repair protein ERCC-5

1

0

High-throughput

0.513

High

1037078

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

Small-scale

0.513

High

1253458

NT5C
5'(3')-deoxyribonucleotidase, cytosolic type

1

0

High-throughput

0.513

High

1270284

PRD11
PR domain-containing protein 11

1

0

High-throughput

0.513

High

387219

P53
Cellular tumor antigen p53

1

1

Small-scale

0.501

High

476136

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

574167

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

3

Small-scale

0.500

High

851218

CCNH
Cyclin-H

1

1

Small-scale

0.500

High

228242

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

631535

BRD2
Bromodomain-containing protein 2

1

2

High-throughput

0.479

High

841832

CDK9
Cyclin-dependent kinase 9

1

3

High-throughput

0.479

High

1038906

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

2

High-throughput

0.479

High

1039009

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

2

High-throughput

0.479

High

1039135

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

2

High-throughput

0.479

High

1123385

BRDT
Bromodomain testis-specific protein

1

2

High-throughput

0.479

High

347484

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

569922

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

651845

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

781579

CETN2
Centrin-2

1

0

High-throughput

0.458

High

801926

RECQ1
ATP-dependent DNA helicase Q1

1

0

High-throughput

0.458

High

824239

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

878091

ANM2
Protein arginine N-methyltransferase 2

1

0

High-throughput

0.458

High

941252

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1019048

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1188649

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1200831

SHLD2
Shieldin complex subunit 2

1

0

High-throughput

0.458

High

1236413

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1270280

ZBT10
Zinc finger and BTB domain-containing protein 10

1

0

Small-scale

0.458

High

1270285

ANLN
Anillin

1

0

High-throughput

0.458

High

1270286

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1270288

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.458

High

1270289

RNF11
RING finger protein 11

1

0

Small-scale

0.458

High

163631

BTAF1
TATA-binding protein-associated factor 172

1

0

Small-scale

0.426

High

504500

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.426

High

749732

BRCA1
Breast cancer type 1 susceptibility protein

1

0

Small-scale

0.426

High

1238626

SR1IP
Protein SREK1IP1

2

0

High-throughput

0.316

High

172156

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.279

Low

277266

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.279

Low

672712

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.279

Low

961761

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.279

Low

1085213

PRSS8
Prostasin

1

0

High-throughput

0.279

Low

1259600

THAP3
THAP domain-containing protein 3

1

0

High-throughput

0.279

Low

1270287

LCAP
Leucyl-cystinyl aminopeptidase

1

0

High-throughput

0.279

Low

1270290

TLN1
Talin-1

1

0

High-throughput

0.279

Low

322949

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

1270281

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1270283

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024