HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: EPHA5 (P54756)
Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7)
Gene: EPHA5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 1037
+	Hs
		136300 P85B_HUMAN (1-728): 0: 541: 100.00		EPHA3_HUMAN (51-1037): 0: 1168: 66.53
+	Hs
		136391 P85B_HUMAN (1-728): 0: 541: 100.00		EPHA7_HUMAN (37-1035): 0: 1166: 61.90
+	Hs
		136346 P85B_HUMAN (1-728): 0: 541: 100.00		EPHA4_HUMAN (33-1035): 0: 1165: 62.90
+	Hs
		136302 P85B_HUMAN (1-728): 0: 541: 100.00		EPHB2_HUMAN (60-1034): 0: 1159: 55.98
+	Hs
		136301 P85B_HUMAN (1-728): 0: 541: 100.00		EPHA8_HUMAN (60-1036): 0: 1115: 58.09
+	Hs
		136299 P85B_HUMAN (1-728): 0: 541: 100.00		EPHA2_HUMAN (58-1037): 0: 1054: 50.86
+	Hs
		136289 P85B_HUMAN (1-728): 0: 541: 100.00		EPHA1_HUMAN (47-1028): 0: 946: 41.68
+	Hs
		710402 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		EPHA2_HUMAN (58-1037): 0: 1054: 50.86
+	Hs
		136306 P85B_HUMAN (1-728): 0: 541: 100.00		UFO_HUMAN (293-954): 3.15e-152: 476: 23.37
+	Mm
		148476 P85B_MOUSE (1-728): 3.84e-179: 530: 88.87		UFO_MOUSE (293-959): 7.8e-155: 483: 23.63
+	Hs
		136253 P85B_HUMAN (1-728): 0: 541: 100.00		INSR_HUMAN (381-1021): 4.01e-145: 470: 25.49
+	Hs
		136262 P85B_HUMAN (1-728): 0: 541: 100.00		IGF1R_HUMAN (422-937): 1.1e-135: 444: 27.77
+	Hs
		720285 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		UFO_HUMAN (293-954): 3.15e-152: 476: 23.37
+	Hs
		136264 P85B_HUMAN (1-728): 0: 541: 100.00		HCK_HUMAN (653-933): 1.22e-65: 232: 42.76
+	Hs
		136260 P85B_HUMAN (1-728): 0: 541: 100.00		LYN_HUMAN (659-933): 1.74e-65: 231: 43.68
+	Hs
		136255 P85B_HUMAN (1-728): 0: 541: 100.00		FYN_HUMAN (669-933): 3.13e-64: 229: 44.20
+	Hs
		465593 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		IGF1R_HUMAN (422-937): 1.1e-135: 444: 27.77
+	Hs
		473453 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		HCK_HUMAN (653-933): 1.22e-65: 232: 42.76
+	Hs
		463686 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		LYN_HUMAN (659-933): 1.74e-65: 231: 43.68
+	Hs
		440656 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		FYN_HUMAN (669-933): 3.13e-64: 229: 44.20