HitPredict

Interactor 1: UFO (P30530)
Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene)
Gene: AXL

Interactor 2: P55G (Q92569)
Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK)
Gene: PIK3R3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.80	0.528

Property	Details
Experiments	12470648
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 894 Hs			1 461
+	Hs
		699606 UFO_HUMAN (1-894): 0: 782: 100.00		P85A_HUMAN (48-455): 1.82e-102: 323: 79.41
+	Hs
		136306 UFO_HUMAN (1-894): 0: 782: 100.00		P85B_HUMAN (56-453): 1.57e-98: 313: 74.12
+	Hs
		699596 EPHA3_HUMAN (2-810): 0: 656: 19.95		P85A_HUMAN (48-455): 1.82e-102: 323: 79.41
+	Hs
		136300 EPHA3_HUMAN (2-810): 0: 656: 19.95		P85B_HUMAN (56-453): 1.57e-98: 313: 74.12
+	Hs
		699663 EPHA4_HUMAN (2-836): 0: 645: 19.10		P85A_HUMAN (48-455): 1.82e-102: 323: 79.41
+	Hs
		362173 EPHA3_HUMAN (2-810): 0: 656: 19.95		ABL1_HUMAN (33-461): 3.7e-93: 306: 16.59
+	Hs
		136346 EPHA4_HUMAN (2-836): 0: 645: 19.10		P85B_HUMAN (56-453): 1.57e-98: 313: 74.12
+	Mm
		362442 EPHA4_MOUSE (2-836): 0: 647: 19.32		ABL1_MOUSE (33-461): 6.51e-94: 308: 16.81
+	Hs
		720150 UFO_HUMAN (1-894): 0: 782: 100.00		ABL2_HUMAN (301-459): 1.22e-23: 106: 23.93
+	Hs
		439967 UFO_HUMAN (1-894): 0: 782: 100.00		LCK_HUMAN (309-458): 5.75e-23: 103: 25.95
+	Hs
		557126 UFO_HUMAN (1-894): 0: 782: 100.00		SRC_HUMAN (324-459): 7.1e-21: 97.3: 24.31
+	Hs
		193214 UFO_HUMAN (1-894): 0: 782: 100.00		SOCS1_HUMAN (46-169): 5.6e-13: 69.8: 23.20
+	Hs
		440391 EPHA3_HUMAN (2-810): 0: 656: 19.95		FYN_HUMAN (323-459): 5.41e-23: 103: 25.52
+	Hs
		557120 EPHA3_HUMAN (2-810): 0: 656: 19.95		SRC_HUMAN (324-459): 7.1e-21: 97.3: 24.31
+	Hs
		463359 EPHA3_HUMAN (2-810): 0: 656: 19.95		LYN_HUMAN (245-458): 1.18e-20: 96.5: 19.91
+	Mm
		813512 EPHA4_MOUSE (2-836): 0: 647: 19.32		FYN_MOUSE (323-459): 5.12e-23: 103: 25.52
+	Hs
		440462 EPHA4_HUMAN (2-836): 0: 645: 19.10		FYN_HUMAN (323-459): 5.41e-23: 103: 25.52
+	Hs
		557189 EPHA4_HUMAN (2-836): 0: 645: 19.10		SRC_HUMAN (324-459): 7.1e-21: 97.3: 24.31
+	Hs
		463419 EPHA4_HUMAN (2-836): 0: 645: 19.10		LYN_HUMAN (245-458): 1.18e-20: 96.5: 19.91
+	Hs
		599278 EPHA4_HUMAN (2-836): 0: 645: 19.10		PLCG2_HUMAN (337-452): 7.01e-12: 69.8: 33.33