HitPredict

Interactor 1: TRAF5 (O00463)
TNF receptor-associated factor 5 (RING finger protein 84)
Gene: TRAF5

Interactor 2: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.731

Property	Details
Experiments	36045679, 26221961, 27348524, 31390091, 31806368, 20161788
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction GO:0035591 - signaling adaptor activity GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 557 Hs			1 540
+	Hs
		1094920 TRAF3_HUMAN (4-556): 6.39e-122: 372: 41.06		MAVS_HUMAN (1-540): 6.17e-72: 240: 100.00
+	Mm
		999818 TRAF5_MOUSE (1-557): 2.64e-146: 434: 79.57		MAVS_MOUSE (1-538): 3.91e-43: 162: 47.68
+	Hs
		1090748 TRAF2_HUMAN (28-554): 5.57e-103: 321: 31.84		MAVS_HUMAN (1-540): 6.17e-72: 240: 100.00
+	Mm
		1221533 TRAF3_MOUSE (2-556): 4.47e-124: 377: 41.27		MAVS_MOUSE (1-538): 3.91e-43: 162: 47.68
+	Hs
		1278156 TRAF6_HUMAN (21-551): 7.73e-81: 264: 22.02		MAVS_HUMAN (1-540): 6.17e-72: 240: 100.00
+	Hs
		623408 RO52_HUMAN (32-468): 7.46e-77: 252: 11.16		MAVS_HUMAN (1-540): 6.17e-72: 240: 100.00
+	Hs
		1093864 TRAF1_HUMAN (161-552): 9.41e-75: 245: 29.51		MAVS_HUMAN (1-540): 6.17e-72: 240: 100.00
+	Mm
		811923 TRAF2_MOUSE (28-554): 4.41e-102: 318: 32.96		MAVS_MOUSE (1-538): 3.91e-43: 162: 47.68
+	Mm
		1189884 TRAF3_MOUSE (2-556): 4.47e-124: 377: 41.27		SC24A_MOUSE (91-490): 6.93e-17: 86.4: 16.63
+	Hs
		1278098 TRIM7_HUMAN (18-469): 4.35e-60: 209: 12.04		MAVS_HUMAN (1-540): 6.17e-72: 240: 100.00
+	Mm
		107071 TRAF3_MOUSE (2-556): 4.47e-124: 377: 41.27		F8VPR5_MOUSE (82-395): 1.46e-11: 69.8: 14.24
+	Mm
		999875 TRAF6_MOUSE (21-551): 6.16e-83: 270: 22.20		MAVS_MOUSE (1-538): 3.91e-43: 162: 47.68
+	Mm
		1189994 Q3UCL2_MOUSE (34-468): 5.37e-75: 247: 11.90		MAVS_MOUSE (1-538): 3.91e-43: 162: 47.68
+	Hs
		1125141 TRI25_HUMAN (38-387): 1.07e-43: 166: 15.43		MAVS_HUMAN (1-540): 6.17e-72: 240: 100.00
+	Hs
		1278097 TRI31_HUMAN (34-365): 4.86e-41: 155: 16.42		MAVS_HUMAN (1-540): 6.17e-72: 240: 100.00
+	Hs
		1278059 RN166_HUMAN (36-211): 2.38e-12: 68.8: 22.51		MAVS_HUMAN (1-540): 6.17e-72: 240: 100.00
+	Hs
		572271 TRI27_HUMAN (32-469): 3.59e-68: 230: 10.97		MAGL2_HUMAN (44-521): 5.97e-10: 64.4: 11.55
+	Hs
		1089223 TRI26_HUMAN (39-383): 1.17e-44: 167: 13.92		HUWE1_HUMAN (79-539): 2.9e-23: 106: 13.36
+	Hs
		1125142 TRI25_HUMAN (38-387): 1.07e-43: 166: 15.43		HUWE1_HUMAN (79-539): 2.9e-23: 106: 13.36