HitPredict

Interactor 1: TRAF6 (P70196)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Interactor 2: MAVS (Q8VCF0)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23951545
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction GO:0032481 - positive regulation of type I interferon production GO:0032755 - positive regulation of interleukin-6 production
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 530 Mm			1 503
+	Hs
		1278156 TRAF6_HUMAN (1-530): 2.33e-139: 414: 87.93		MAVS_HUMAN (1-501): 8.79e-52: 186: 46.30
+	Mm
		811923 TRAF2_MOUSE (38-508): 1.78e-101: 316: 25.75		MAVS_MOUSE (1-503): 7.43e-63: 215: 100.00
+	Hs
		1047155 TRAF6_HUMAN (1-530): 2.33e-139: 414: 87.93		IF4G1_HUMAN (78-500): 1.34e-21: 101: 12.67
+	Hs
		1090748 TRAF2_HUMAN (38-508): 3.93e-101: 315: 25.55		MAVS_HUMAN (1-501): 8.79e-52: 186: 46.30
+	Mm
		1221533 TRAF3_MOUSE (14-510): 1.65e-86: 279: 21.64		MAVS_MOUSE (1-503): 7.43e-63: 215: 100.00
+	Mm
		999818 TRAF5_MOUSE (43-508): 1.42e-81: 266: 24.54		MAVS_MOUSE (1-503): 7.43e-63: 215: 100.00
+	Hs
		1094920 TRAF3_HUMAN (14-510): 3.16e-85: 276: 20.94		MAVS_HUMAN (1-501): 8.79e-52: 186: 46.30
+	Hs
		136703 TRAF5_HUMAN (43-508): 9.42e-81: 264: 24.35		MAVS_HUMAN (1-501): 8.79e-52: 186: 46.30
+	Hs
		1046982 TRAF2_HUMAN (38-508): 3.93e-101: 315: 25.55		IF4G1_HUMAN (78-500): 1.34e-21: 101: 12.67
+	Hs
		1093864 TRAF1_HUMAN (50-511): 1.91e-64: 217: 18.63		MAVS_HUMAN (1-501): 8.79e-52: 186: 46.30
+	Mm
		1189994 Q3UCL2_MOUSE (60-417): 4.5e-40: 152: 14.29		MAVS_MOUSE (1-503): 7.43e-63: 215: 100.00
+	Hs
		1125141 TRI25_HUMAN (63-387): 4.99e-43: 164: 13.39		MAVS_HUMAN (1-501): 8.79e-52: 186: 46.30
+	Hs
		623408 RO52_HUMAN (56-417): 2.01e-42: 159: 12.88		MAVS_HUMAN (1-501): 8.79e-52: 186: 46.30
+	Hs
		1278097 TRI31_HUMAN (57-384): 7.44e-42: 157: 14.71		MAVS_HUMAN (1-501): 8.79e-52: 186: 46.30
+	Hs
		1278059 RN166_HUMAN (61-194): 9.37e-15: 75.7: 23.53		MAVS_HUMAN (1-501): 8.79e-52: 186: 46.30
+	Hs
		1278068 RN125_HUMAN (68-194): 2.24e-11: 65.7: 26.03		MAVS_HUMAN (1-501): 8.79e-52: 186: 46.30
+	Hs
		1278159 RN114_HUMAN (63-232): 2.74e-11: 65.3: 19.67		MAVS_HUMAN (1-501): 8.79e-52: 186: 46.30