HitPredict

Interactor 1: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Interactor 2: ASB9 (Q96DX5)
Ankyrin repeat and SOCS box protein 9 (ASB-9)
Gene: ASB9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.965

Property	Details
Experiments	23806657, 26186194, 28514442, 33961781, 20302626, 17148442, 23837592, 24337577, unassigned3799
Identification Methods	x-ray crystallography, affinity chromatography technology, biochemical, anti tag coimmunoprecipitation
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	Ank_2~Cullin, Cullin~SOCS_box
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0031466 - Cul5-RING ubiquitin ligase complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Hs			1 294
+	Hs
		1359846 CUL5_HUMAN (1-780): 0: 791: 100.00		ASB5_HUMAN (36-293): 3.11e-72: 226: 52.90
+	Hs
		592933 CUL3_HUMAN (8-780): 0: 753: 22.96		ANK1_HUMAN (4-294): 5.02e-76: 254: 20.31
+	Hs
		1361058 CUL5_HUMAN (1-780): 0: 791: 100.00		ASB13_HUMAN (9-173): 4.49e-34: 126: 28.49
+	Hs
		920438 CUL3_HUMAN (8-780): 0: 753: 22.96		DAPK1_HUMAN (2-195): 6.89e-42: 155: 18.97
+	Hs
		1114326 CUL3_HUMAN (8-780): 0: 753: 22.96		EHMT1_HUMAN (29-180): 1.14e-37: 143: 26.62
+	Hs
		1113541 CUL3_HUMAN (8-780): 0: 753: 22.96		ANS1B_HUMAN (73-287): 4.13e-35: 136: 21.53
+	Hs
		943938 CUL1_HUMAN (11-780): 0: 746: 27.84		RIPK4_HUMAN (1-163): 1.48e-37: 143: 25.15
+	Hs
		1360793 CUL5_HUMAN (1-780): 0: 791: 100.00		ASB11_HUMAN (110-287): 1.92e-22: 96.8: 20.99
+	Hs
		1371865 CUL5_HUMAN (1-780): 0: 791: 100.00		ASB7_HUMAN (121-284): 1.59e-22: 96.8: 20.47
+	Hs
		1112713 CUL1_HUMAN (11-780): 0: 746: 27.84		Q9H4D1_HUMAN (1-163): 4.76e-37: 141: 25.15
+	Hs
		1371912 CUL5_HUMAN (1-780): 0: 791: 100.00		ASB3_HUMAN (37-219): 1.21e-20: 93.6: 31.25
+	Hs
		1257012 CUL5_HUMAN (1-780): 0: 791: 100.00		ASB18_HUMAN (38-236): 6.28e-20: 91.3: 34.29
+	Hs
		1371913 CUL5_HUMAN (1-780): 0: 791: 100.00		ASB1_HUMAN (38-293): 9.88e-20: 89.4: 29.24
+	Hs
		1113853 CUL3_HUMAN (8-780): 0: 753: 22.96		ASB13_HUMAN (9-173): 4.49e-34: 126: 28.49
+	Hs
		1371839 CUL5_HUMAN (1-780): 0: 791: 100.00		ASB2_HUMAN (72-254): 4.01e-10: 62.4: 28.34
+	Hs
		1091393 CUL3_HUMAN (8-780): 0: 753: 22.96		ANK3_HUMAN (206-292): 1.65e-20: 93.7: 15.73
+	Hs
		1113629 CUL3_HUMAN (8-780): 0: 753: 22.96		ANKH1_HUMAN (192-294): 2.96e-20: 92.9: 14.15
+	Hs
		1091394 CUL4A_HUMAN (16-780): 0: 743: 24.48		ANK3_HUMAN (206-292): 1.65e-20: 93.7: 15.73
+	Hs
		177215 CUL3_HUMAN (8-780): 0: 753: 22.96		ANR28_HUMAN (2-89): 3.59e-09: 59.4: 15.22
+	Hs
		1112665 CUL1_HUMAN (11-780): 0: 746: 27.84		ASB2_HUMAN (72-254): 4.01e-10: 62.4: 28.34