HitPredict

Interactor 1: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Interactor 2: FEM1C (Q96JP0)
Protein fem-1 homolog C (FEM1c) (FEM1-gamma)
Gene: FEM1C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Cullin
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Hs			1 617
+	Hs
		1371851 CUL5_HUMAN (1-780): 0: 791: 100.00		FEM1A_HUMAN (1-616): 5.28e-107: 339: 63.13
+	Hs
		592933 CUL3_HUMAN (8-780): 0: 753: 22.96		ANK1_HUMAN (1-457): 4.85e-104: 348: 20.95
+	Hs
		1112956 CUL2_HUMAN (6-780): 0: 697: 26.36		FEM1C_HUMAN (1-617): 1.75e-127: 390: 100.00
+	Hs
		1091393 CUL3_HUMAN (8-780): 0: 753: 22.96		ANK3_HUMAN (3-343): 4.97e-83: 287: 21.35
+	Hs
		1112975 CUL2_HUMAN (6-780): 0: 697: 26.36		FEM1A_HUMAN (1-616): 5.28e-107: 339: 63.13
+	Hs
		1091394 CUL4A_HUMAN (16-780): 0: 743: 24.48		ANK3_HUMAN (3-343): 4.97e-83: 287: 21.35
+	Ce
		603141 CUL2_CAEEL (7-780): 0: 642: 24.85		FEM1_CAEEL (4-616): 1.27e-121: 376: 32.88
+	Hs
		1114688 CUL3_HUMAN (8-780): 0: 753: 22.96		INVS_HUMAN (4-439): 1.47e-64: 231: 14.91
+	Hs
		1371859 CUL5_HUMAN (1-780): 0: 791: 100.00		TNKS2_HUMAN (311-616): 3.27e-39: 156: 15.53
+	Hs
		1113629 CUL3_HUMAN (8-780): 0: 753: 22.96		ANKH1_HUMAN (238-613): 1.37e-41: 164: 12.60
+	Hs
		1113716 CUL3_HUMAN (8-780): 0: 753: 22.96		ANR52_HUMAN (341-612): 1.37e-33: 139: 11.32
+	Hs
		1371839 CUL5_HUMAN (1-780): 0: 791: 100.00		ASB2_HUMAN (231-572): 1.14e-12: 72.8: 15.65
+	Hs
		1371894 CUL5_HUMAN (1-780): 0: 791: 100.00		FEM1B_HUMAN (491-617): 4.94e-12: 70.9: 11.77
+	Hs
		1113489 CUL3_HUMAN (8-780): 0: 753: 22.96		ESPNL_HUMAN (5-240): 5.01e-21: 100: 32.08
+	Hs
		177215 CUL3_HUMAN (8-780): 0: 753: 22.96		ANR28_HUMAN (488-613): 1.98e-16: 85.5: 20.47
+	Hs
		1112665 CUL1_HUMAN (11-780): 0: 746: 27.84		ASB2_HUMAN (231-572): 1.14e-12: 72.8: 15.65
+	Hs
		1115010 CUL4A_HUMAN (16-780): 0: 743: 24.48		ASB2_HUMAN (231-572): 1.14e-12: 72.8: 15.65
+	Hs
		1115134 CUL4A_HUMAN (16-780): 0: 743: 24.48		FEM1B_HUMAN (491-617): 4.94e-12: 70.9: 11.77
+	Hs
		1112963 CUL2_HUMAN (6-780): 0: 697: 26.36		ASB2_HUMAN (231-572): 1.14e-12: 72.8: 15.65
+	Hs
		1113017 CUL2_HUMAN (6-780): 0: 697: 26.36		FEM1B_HUMAN (491-617): 4.94e-12: 70.9: 11.77