Protein: FEM1B
Protein fem-1 homolog B (FEM1b) (FEM1-beta) (Fem-1-like death receptor-binding protein alpha) (Fem-1-like in apoptotic pathway protein alpha) (F1A-alpha)

Gene: FEM1B
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q9UK73

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0005123 - death receptor binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1113017

CUL2
Cullin-2

5

16

Small-scale

0.927

High

1371894

CUL5
Cullin-5

4

16

Small-scale

0.903

High

1451413

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

2

16

Small-scale

0.821

High

1206596

RAB41
Ras-related protein Rab-41

2

3

High-throughput

0.811

High

1326650

KIF2B
Kinesin-like protein KIF2B

2

5

High-throughput

0.811

High

1400681

RHG07
Rho GTPase-activating protein 7

2

7

High-throughput

0.811

High

1460937

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

2

4

High-throughput

0.811

High

1272589

CSN6
COP9 signalosome complex subunit 6

6

1

High-throughput

0.735

High

171782

GAK
Cyclin-G-associated kinase

1

5

High-throughput

0.691

High

354798

PAK4
Serine/threonine-protein kinase PAK 4

1

4

High-throughput

0.691

High

1243067

PKN3
Serine/threonine-protein kinase N3

1

7

High-throughput

0.691

High

1315933

RASEF
Ras and EF-hand domain-containing protein

1

4

High-throughput

0.691

High

1438966

ARGAL
Rho guanine nucleotide exchange factor 10-like protein

1

13

High-throughput

0.691

High

958734

CSN2
COP9 signalosome complex subunit 2

4

3

High-throughput

0.691

High

1460936

CSN3
COP9 signalosome complex subunit 3

4

2

High-throughput

0.691

High

722763

AL1B1
Aldehyde dehydrogenase X, mitochondrial

3

2

High-throughput

0.667

High

984013

RBX1
E3 ubiquitin-protein ligase RBX1

3

2

Small-scale

0.667

High

1279511

CMKMT
Calmodulin-lysine N-methyltransferase

3

1

High-throughput

0.667

High

1431388

EPN3
Epsin-3

3

5

High-throughput

0.667

High

1371214

GLMN
Glomulin

3

1

High-throughput

0.662

High

1147146

ELOC
Elongin-C

3

2

Small-scale

0.656

High

1147304

ELOB
Elongin-B

3

2

Small-scale

0.656

High

1370450

CSN5
COP9 signalosome complex subunit 5

3

2

High-throughput

0.650

High

1435892

MB12B
Multivesicular body subunit 12B

3

0

High-throughput

0.638

High

942168

WNT3A
Protein Wnt-3a

4

1

High-throughput

0.630

High

350753

NOE2
Noelin-2

2

1

High-throughput

0.628

High

1219937

BSPRY
B box and SPRY domain-containing protein

2

6

High-throughput

0.628

High

1388063

TRI44
Tripartite motif-containing protein 44

2

5

High-throughput

0.628

High

1212181

ODAD2
Outer dynein arm-docking complex subunit 2

1

10

High-throughput

0.618

High

1115134

CUL4A
Cullin-4A

1

16

High-throughput

0.618

High

1348696

SHKB1
SH3KBP1-binding protein 1

3

16

High-throughput

0.604

High

50943

SYCE3
Synaptonemal complex central element protein 3

2

0

High-throughput

0.602

High

349716

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

2

0

High-throughput

0.602

High

1406138

CSN8
COP9 signalosome complex subunit 8

2

0

High-throughput

0.602

High

1410916

GORS1
Golgi reassembly-stacking protein 1

2

0

High-throughput

0.602

High

1437205

CSN7B
COP9 signalosome complex subunit 7b

2

0

High-throughput

0.602

High

1094441

CSN1
COP9 signalosome complex subunit 1

2

3

High-throughput

0.601

High

1147707

TOM20
Mitochondrial import receptor subunit TOM20 homolog

2

1

High-throughput

0.601

High

1393265

SENP5
Sentrin-specific protease 5

2

2

High-throughput

0.601

High

163189

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.586

High

884855

PPM1F
Protein phosphatase 1F

1

1

Small-scale

0.578

High

1449124

TOM22
Mitochondrial import receptor subunit TOM22 homolog

2

0

High-throughput

0.576

High

1460177

VATH
V-type proton ATPase subunit H

2

0

High-throughput

0.576

High

1054156

BTK
Tyrosine-protein kinase BTK

1

8

High-throughput

0.575

High

466712

GLI1
Zinc finger protein GLI1

1

5

Small-scale

0.561

High

281450

GGYF1
GRB10-interacting GYF protein 1

1

6

High-throughput

0.536

High

682650

S100P
Protein S100-P

1

3

High-throughput

0.536

High

1052921

HME1
Homeobox protein engrailed-1

1

16

High-throughput

0.536

High

1244466

DCNL2
DCN1-like protein 2

1

1

High-throughput

0.536

High

1391973

DCNL1
DCN1-like protein 1

1

1

High-throughput

0.536

High

67299

YJEN3
YjeF N-terminal domain-containing protein 3

1

0

High-throughput

0.513

High

280967

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.513

High

686759

CNTF
Ciliary neurotrophic factor

1

0

High-throughput

0.513

High

777596

PDE6B
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

1

0

High-throughput

0.513

High

1119495

RUNX2
Runt-related transcription factor 2

1

0

High-throughput

0.513

High

1154956

NEDD8
Ubiquitin-like protein NEDD8

1

0

High-throughput

0.513

High

1228189

SLIP
Nuclear GTPase SLIP-GC

1

0

High-throughput

0.513

High

1352587

AF1L1
Actin filament-associated protein 1-like 1

1

0

High-throughput

0.513

High

1360286

CSN9
COP9 signalosome complex subunit 9

1

0

High-throughput

0.513

High

1353221

SMCR8
Guanine nucleotide exchange protein SMCR8

1

0

Small-scale

0.494

High

335669

GCNT3
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

1

1

High-throughput

0.489

High

706346

S10A2
Protein S100-A2

1

3

High-throughput

0.489

High

1272908

SYT13
Synaptotagmin-13

1

2

High-throughput

0.489

High

1433630

SMOC1
SPARC-related modular calcium-binding protein 1

1

1

High-throughput

0.489

High

1407371

NKX31
Homeobox protein Nkx-3.1

1

11

Small-scale

0.481

High

1406173

RAD9A
Cell cycle checkpoint control protein RAD9A

1

0

Small-scale

0.480

High

294507

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

376922

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

2

High-throughput

0.479

High

844077

HD
Huntingtin

1

2

High-throughput

0.479

High

993014

RACK1
Small ribosomal subunit protein RACK1

1

7

Small-scale

0.479

High

1066254

DMWD
Dystrophia myotonica WD repeat-containing protein

1

6

High-throughput

0.479

High

1126845

SLBP
Histone RNA hairpin-binding protein

1

4

Small-scale

0.479

High

1353509

FNIP1
Folliculin-interacting protein 1

1

1

Small-scale

0.479

High

1435429

EGLN3
Prolyl hydroxylase EGLN3

1

7

High-throughput

0.479

High

1460016

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

7

Small-scale

0.479

High

271378

DEPD5
GATOR1 complex protein DEPDC5

1

0

Small-scale

0.458

High

1338846

FLCN
Folliculin

1

0

Small-scale

0.458

High

1413215

CSN4
COP9 signalosome complex subunit 4

1

0

High-throughput

0.458

High

1417604

BEX2
Protein BEX2

1

0

Small-scale

0.458

High

1144804

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

1

2

High-throughput

0.445

High

1369320

EDA
Ectodysplasin-A

1

3

High-throughput

0.445

High

1453387

MTCH1
Mitochondrial carrier homolog 1

1

6

High-throughput

0.445

High

245016

KATIP
Katanin-interacting protein

1

0

High-throughput

0.426

High

1326753

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.426

High

1142269

CD5R1
Cyclin-dependent kinase 5 activator 1

1

1

Small-scale

0.408

High

1310042

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

2

0

High-throughput

0.328

High

1278650

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

1218512

K0319
Dyslexia-associated protein KIAA0319

1

0

Small-scale

0.265

Low

1091913

NPRL3
GATOR1 complex protein NPRL3

1

0

Small-scale

0.249

Low

1356196

NPRL2
GATOR1 complex protein NPRL2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025