Protein: KLHL2
Kelch-like protein 2 (Actin-binding protein Mayven)

Gene: KLHL2
Organism: Homo sapiens
Interactions: 94
UniProt ID: O95198

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0003779 - actin binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0015629 - actin cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

307170

CUL3
Cullin-3

9

20

Small-scale

0.971

High

307182

KLH12
Kelch-like protein 12

8

19

Small-scale

0.968

High

307172

KEAP1
Kelch-like ECH-associated protein 1

6

18

Small-scale

0.948

High

307154

KLHL2
Kelch-like protein 2

5

18

Small-scale

0.922

High

307227

KLHL3
Kelch-like protein 3

4

18

High-throughput

0.894

High

307226

FXL17
F-box/LRR-repeat protein 17

3

15

High-throughput

0.861

High

307188

KLH17
Kelch-like protein 17

3

17

High-throughput

0.839

High

307177

CUL7
Cullin-7

2

1

High-throughput

0.789

High

307159

BCAM
Basal cell adhesion molecule

2

7

High-throughput

0.755

High

307206

NACC1
Nucleus accumbens-associated protein 1

1

18

Small-scale

0.713

High

307216

WNK1
Serine/threonine-protein kinase WNK1

4

13

Small-scale

0.683

High

307217

UCK1
Uridine-cytidine kinase 1

3

1

Small-scale

0.678

High

307163

TSN5
Tetraspanin-5

3

2

High-throughput

0.656

High

307173

ARHG7
Rho guanine nucleotide exchange factor 7

3

4

Small-scale

0.656

High

307207

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

3

9

Small-scale

0.656

High

307211

WNK3
Serine/threonine-protein kinase WNK3

3

8

Small-scale

0.656

High

307200

TMA16
Translation machinery-associated protein 16

4

1

High-throughput

0.637

High

307202

WNK4
Serine/threonine-protein kinase WNK4

2

8

Small-scale

0.633

High

132691

SDCB1
Syntenin-1

2

6

High-throughput

0.628

High

155500

TNPO2
Transportin-2

2

2

High-throughput

0.628

High

307169

DCTN2
Dynactin subunit 2

3

0

High-throughput

0.628

High

135756

P3C2B
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

2

1

High-throughput

0.611

High

255395

OBSL1
Obscurin-like protein 1

2

4

High-throughput

0.611

High

257002

DJC13
DnaJ homolog subfamily C member 13

2

6

High-throughput

0.611

High

307157

ACTY
Beta-centractin

2

9

High-throughput

0.611

High

307162

ACTZ
Alpha-centractin

2

9

High-throughput

0.611

High

307167

XIAP
E3 ubiquitin-protein ligase XIAP

2

1

High-throughput

0.611

High

307175

DCTN1
Dynactin subunit 1

2

4

High-throughput

0.611

High

307195

FBXW8
F-box/WD repeat-containing protein 8

2

4

High-throughput

0.611

High

307198

UPP
Uracil phosphoribosyltransferase homolog

2

1

High-throughput

0.611

High

307199

GASP2
G-protein coupled receptor-associated sorting protein 2

2

1

High-throughput

0.611

High

307203

SCYL1
N-terminal kinase-like protein

2

4

High-throughput

0.611

High

307204

TRI47
E3 ubiquitin-protein ligase TRIM47

2

7

High-throughput

0.611

High

307209

DCTN5
Dynactin subunit 5

2

1

High-throughput

0.611

High

307212

TRIM8
E3 ubiquitin-protein ligase TRIM8

2

8

High-throughput

0.611

High

307213

TRIM9
E3 ubiquitin-protein ligase TRIM9

2

9

High-throughput

0.611

High

307221

UCKL1
Uridine-cytidine kinase-like 1

2

2

High-throughput

0.611

High

307223

ARP10
Actin-related protein 10

2

8

High-throughput

0.611

High

307229

DP13A
DCC-interacting protein 13-alpha

2

3

High-throughput

0.611

High

307230

ACINU
Apoptotic chromatin condensation inducer in the nucleus

2

3

High-throughput

0.611

High

307171

BYST
Bystin

2

1

High-throughput

0.606

High

307179

CDC37
Hsp90 co-chaperone Cdc37

2

1

High-throughput

0.606

High

307189

PADI6
Protein-arginine deiminase type-6

2

1

High-throughput

0.606

High

307193

TRI50
E3 ubiquitin-protein ligase TRIM50

2

2

High-throughput

0.606

High

307201

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

3

High-throughput

0.606

High

126667

DCTN6
Dynactin subunit 6

2

0

High-throughput

0.585

High

196389

SI1L1
Signal-induced proliferation-associated 1-like protein 1

2

0

High-throughput

0.585

High

278579

DCTN3
Dynactin subunit 3

2

0

High-throughput

0.585

High

307156

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

2

0

High-throughput

0.585

High

307191

FBX33
F-box only protein 33

2

0

High-throughput

0.585

High

307208

TCF25
Ribosome quality control complex subunit TCF25

2

0

High-throughput

0.585

High

307214

CCDC8
Coiled-coil domain-containing protein 8

2

0

High-throughput

0.585

High

307219

DBLOH
Diablo IAP-binding mitochondrial protein

2

0

High-throughput

0.585

High

307228

DCTN4
Dynactin subunit 4

2

0

High-throughput

0.585

High

307233

SYYM
Tyrosine--tRNA ligase, mitochondrial

2

0

High-throughput

0.585

High

307210

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

0

High-throughput

0.580

High

307218

CWC22
Pre-mRNA-splicing factor CWC22 homolog

2

0

High-throughput

0.580

High

307225

KLH13
Kelch-like protein 13

1

18

High-throughput

0.575

High

307205

CCD43
Coiled-coil domain-containing protein 43

1

1

High-throughput

0.573

High

307166

ACTC
Actin, alpha cardiac muscle 1

1

7

Small-scale

0.561

High

307174

GIT2
ARF GTPase-activating protein GIT2

2

4

High-throughput

0.558

High

307186

PHLB3
Pleckstrin homology-like domain family B member 3

2

4

High-throughput

0.558

High

307176

ELOA1
Elongin-A

2

1

High-throughput

0.553

High

307215

CMIP1
Ciliary microtubule inner protein 1

2

1

High-throughput

0.553

High

307192

Q86WV7
Coiled-coil domain-containing protein 43

1

1

High-throughput

0.538

High

307168

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

6

High-throughput

0.536

High

307194

NUDC3
NudC domain-containing protein 3

1

20

High-throughput

0.536

High

307222

ALKB4
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

1

1

High-throughput

0.536

High

307184

Q5TZN3
Ubiquitin-conjugating enzyme E2 C

1

7

High-throughput

0.515

High

307183

KLH26
Kelch-like protein 26

1

18

High-throughput

0.514

High

307160

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

5

Small-scale

0.501

High

64777

TBKB1
TANK-binding kinase 1-binding protein 1

1

2

Small-scale

0.481

High

135913

UBE2C
Ubiquitin-conjugating enzyme E2 C

1

7

High-throughput

0.481

High

307165

UBC9
SUMO-conjugating enzyme UBC9

1

10

High-throughput

0.481

High

307197

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.481

High

159127

CSKP
Peripheral plasma membrane protein CASK

1

3

High-throughput

0.479

High

307234

WNK2
Serine/threonine-protein kinase WNK2

1

13

Small-scale

0.479

High

307235

ARI1
E3 ubiquitin-protein ligase ARIH1

1

12

High-throughput

0.479

High

307181

Q4G0R1
PIBF1 protein

1

1

High-throughput

0.470

High

307190

Q7KZS0
SUMO-conjugating enzyme UBC9

1

11

High-throughput

0.470

High

307178

RNPS1
RNA-binding protein with serine-rich domain 1

1

0

High-throughput

0.458

High

307220

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.457

High

307164

SKP1
S-phase kinase-associated protein 1

1

4

High-throughput

0.445

High

307224

RRBP1
Ribosome-binding protein 1

1

7

High-throughput

0.437

High

307196

ZN114
Zinc finger protein 114

4

0

High-throughput

0.364

High

307158

CLK2
Dual specificity protein kinase CLK2

3

0

High-throughput

0.352

High

307155

TXD12
Thioredoxin domain-containing protein 12

3

0

High-throughput

0.348

High

307185

FHI2A
FHF complex subunit HOOK interacting protein 2A

2

0

High-throughput

0.318

High

307161

MFAP1
Microfibrillar-associated protein 1

2

0

High-throughput

0.316

High

307231

NP1L2
Nucleosome assembly protein 1-like 2

2

0

High-throughput

0.316

High

307180

ZN423
Zinc finger protein 423

1

0

High-throughput

0.279

Low

307187

SAMD1
Sterile alpha motif domain-containing protein 1

1

0

High-throughput

0.249

Low

307232

EPDR1
Mammalian ependymin-related protein 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024