HitPredict

Interactor 1: Q961D1 (Q961D1)
Cyclin-K
Gene: CycK

Interactor 2: CDK12 (Q9VP22)
Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 12) (dCdk12)
Gene: CDK12

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.870

Property	Details
Experiments	20952539, 22036573, 16603075, 38944040
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cyclin_N~Pkinase, CycT2-like_C~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0008024 - cyclin/CDK positive transcription elongation factor complex GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 400 Dm			1 1157
+	Dm
		660401 Q961D1_DROME (1-400): 2.03e-124: 367: 100.00		CDK1_DROME (801-1101): 8.19e-134: 410: 37.95
+	At
		1341905 CCL11_ARATH (4-282): 1.93e-82: 260: 25.86		Q9CAG1_ARATH (382-1156): 7.25e-136: 432: 24.69
+	At
		1341906 CCL11_ARATH (4-282): 1.93e-82: 260: 25.86		CDKG1_ARATH (500-1118): 1.02e-134: 424: 28.71
+	Hs
		667764 CCNA1_HUMAN (1-274): 1.02e-79: 254: 15.58		CDK2_HUMAN (801-1104): 7.12e-140: 426: 40.00
+	At
		1300177 CCT14_ARATH (1-330): 4.44e-76: 247: 27.78		CDKC1_ARATH (790-1143): 3.87e-134: 419: 48.33
+	At
		1426030 CCT15_ARATH (4-334): 6.86e-75: 245: 28.34		CDKC1_ARATH (790-1143): 3.87e-134: 419: 48.33
+	At
		663906 CCA31_ARATH (5-279): 4.48e-83: 259: 15.83		CDKA1_ARATH (801-1101): 6.65e-132: 405: 41.45
+	At
		663871 CCA21_ARATH (8-269): 1.17e-81: 258: 15.97		CDKA1_ARATH (801-1101): 6.65e-132: 405: 41.45
+	Hs
		443299 CCNA1_HUMAN (1-274): 1.02e-79: 254: 15.58		CDK1_HUMAN (801-1102): 1.17e-132: 407: 39.80
+	At
		1300176 CCT14_ARATH (1-330): 4.44e-76: 247: 27.78		CDKC2_ARATH (790-1147): 1.25e-131: 413: 47.80
+	At
		1355591 CCT15_ARATH (4-334): 6.86e-75: 245: 28.34		CDKC2_ARATH (790-1147): 1.25e-131: 413: 47.80
+	At
		663870 CCB12_ARATH (1-283): 1.23e-79: 253: 14.13		CDKA1_ARATH (801-1101): 6.65e-132: 405: 41.45
+	At
		663913 CCB23_ARATH (1-272): 6.44e-78: 248: 15.07		CDKA1_ARATH (801-1101): 6.65e-132: 405: 41.45
+	At
		663898 CCA32_ARATH (5-269): 4.47e-78: 247: 14.82		CDKA1_ARATH (801-1101): 6.65e-132: 405: 41.45
+	Mm
		1021258 CCNA1_MOUSE (5-274): 1.48e-77: 247: 15.44		CDK2_MOUSE (801-1104): 1.68e-130: 403: 34.28
+	At
		663900 CCA24_ARATH (4-267): 2.55e-75: 243: 14.93		CDKA1_ARATH (801-1101): 6.65e-132: 405: 41.45
+	Mm
		1408622 CCNT1_MOUSE (4-248): 2.41e-76: 252: 29.88		CDK9_MOUSE (801-1148): 3.17e-122: 382: 43.70
+	Hs
		252236 CCNT2_HUMAN (4-336): 4.76e-76: 251: 27.00		CDK9_HUMAN (801-1148): 2.27e-122: 383: 43.42
+	Mm
		1274590 CCNT2_MOUSE (4-336): 8.53e-74: 245: 26.04		CDK9_MOUSE (801-1148): 3.17e-122: 382: 43.70
+	Dm
		660459 Q961D1_DROME (1-400): 2.03e-124: 367: 100.00		CDK2_DROME (801-1112): 6.54e-67: 229: 40.88