HitPredict

Interactor 1: CDK2 (P23573)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 cognate)
Gene: CDK2

Interactor 2: Q961D1 (Q961D1)
Cyclin-K
Gene: CycK

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	15575970, 16603075, 19079254
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cyclin_N~Pkinase, CycT2-like_C~Pkinase
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 314 Dm			1 400
+	Hs
		667764 CDK2_HUMAN (5-293): 1.43e-142: 405: 64.73		CCNA1_HUMAN (1-274): 1.02e-79: 254: 15.58
+	At
		1341905 Q9CAG1_ARATH (2-309): 4.96e-130: 389: 42.68		CCL11_ARATH (4-282): 1.93e-82: 260: 25.86
+	Hs
		573751 CDK2_HUMAN (5-293): 1.43e-142: 405: 64.73		CCNB1_HUMAN (5-276): 9.32e-74: 238: 14.34
+	Hs
		573801 CDK3_HUMAN (5-300): 5.8e-141: 401: 62.54		CCNB1_HUMAN (5-276): 9.32e-74: 238: 14.34
+	Hs
		629061 CDK2_HUMAN (5-293): 1.43e-142: 405: 64.73		CCNA2_HUMAN (5-273): 1.41e-71: 232: 18.82
+	Hs
		325466 CDK2_HUMAN (5-293): 1.43e-142: 405: 64.73		CCNB2_HUMAN (1-279): 1.2e-71: 231: 12.90
+	Hs
		629100 CDK3_HUMAN (5-300): 5.8e-141: 401: 62.54		CCNA2_HUMAN (5-273): 1.41e-71: 232: 18.82
+	Mm
		1021258 CDK2_MOUSE (5-293): 4.87e-134: 385: 55.00		CCNA1_MOUSE (5-274): 1.48e-77: 247: 15.44
+	At
		1185691 Q9CAG1_ARATH (2-309): 4.96e-130: 389: 42.68		CCA34_ARATH (3-269): 2.25e-75: 240: 15.02
+	Dm
		575837 CDK2_DROME (1-314): 4.81e-139: 397: 100.00		CCNA_DROME (5-272): 5.11e-68: 225: 15.93
+	Hs
		666822 CDK3_HUMAN (5-300): 5.8e-141: 401: 62.54		CCNC_HUMAN (3-249): 8.57e-69: 220: 26.59
+	Mm
		908677 CDK2_MOUSE (5-293): 4.87e-134: 385: 55.00		CCNA2_MOUSE (5-273): 1.06e-72: 235: 18.08
+	Hs
		1025278 CDK3_HUMAN (5-300): 5.8e-141: 401: 62.54		CCNQ_HUMAN (22-239): 1.1e-67: 216: 25.22
+	Dm
		660422 CDK2_DROME (1-314): 4.81e-139: 397: 100.00		CCNC_DROME (3-243): 1.43e-65: 211: 23.98
+	Hs
		667568 CDK2_HUMAN (5-293): 1.43e-142: 405: 64.73		CCND2_HUMAN (16-275): 4.2e-58: 193: 15.27
+	Hs
		667665 CDK2_HUMAN (5-293): 1.43e-142: 405: 64.73		CCNH_HUMAN (21-265): 1.1e-57: 193: 17.86
+	Rn
		1048464 Q6P751_RAT (5-293): 1.32e-142: 405: 64.04		CCND2_RAT (16-275): 6.92e-57: 189: 15.27
+	Hs
		908691 CDK3_HUMAN (5-300): 5.8e-141: 401: 62.54		CCNH_HUMAN (21-265): 1.1e-57: 193: 17.86
+	At
		1355723 Q9CAG1_ARATH (2-309): 4.96e-130: 389: 42.68		CCH11_ARATH (16-287): 1.52e-58: 195: 19.30
+	Mm
		718862 CDK2_MOUSE (5-293): 4.87e-134: 385: 55.00		CCND2_MOUSE (16-263): 4.04e-57: 190: 16.67