HitPredict

Interactor 1: CDK1 (P23572)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: Q961D1 (Q961D1)
Cyclin-K
Gene: CycK

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.785

Property	Details
Experiments	15575970, 16603075
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cyclin_N~Pkinase, CycT2-like_C~Pkinase
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 297 Dm			1 400
+	Hs
		667764 CDK2_HUMAN (1-293): 2.43e-160: 449: 62.80		CCNA1_HUMAN (1-274): 1.02e-79: 254: 15.58
+	Hs
		573751 CDK2_HUMAN (1-293): 2.43e-160: 449: 62.80		CCNB1_HUMAN (5-276): 9.32e-74: 238: 14.34
+	Hs
		629061 CDK2_HUMAN (1-293): 2.43e-160: 449: 62.80		CCNA2_HUMAN (5-273): 1.41e-71: 232: 18.82
+	Hs
		325466 CDK2_HUMAN (1-293): 2.43e-160: 449: 62.80		CCNB2_HUMAN (1-279): 1.2e-71: 231: 12.90
+	Mm
		1021258 CDK2_MOUSE (1-293): 2.15e-151: 428: 53.67		CCNA1_MOUSE (5-274): 1.48e-77: 247: 15.44
+	Hs
		573801 CDK3_HUMAN (1-289): 3.87e-151: 426: 65.40		CCNB1_HUMAN (5-276): 9.32e-74: 238: 14.34
+	Mm
		908677 CDK2_MOUSE (1-293): 2.15e-151: 428: 53.67		CCNA2_MOUSE (5-273): 1.06e-72: 235: 18.08
+	Hs
		629100 CDK3_HUMAN (1-289): 3.87e-151: 426: 65.40		CCNA2_HUMAN (5-273): 1.41e-71: 232: 18.82
+	Hs
		443152 CDK1_HUMAN (1-292): 4.2e-146: 413: 72.95		CCNB1_HUMAN (5-276): 9.32e-74: 238: 14.34
+	Mm
		1021261 CDK2_MOUSE (1-293): 2.15e-151: 428: 53.67		CCNC_MOUSE (3-249): 1.98e-68: 219: 26.19
+	Hs
		251498 CDK1_HUMAN (1-292): 4.2e-146: 413: 72.95		CCNT1_HUMAN (4-307): 1.16e-69: 234: 25.24
+	Hs
		666822 CDK3_HUMAN (1-289): 3.87e-151: 426: 65.40		CCNC_HUMAN (3-249): 8.57e-69: 220: 26.59
+	Hs
		325458 CDK1_HUMAN (1-292): 4.2e-146: 413: 72.95		CCNB2_HUMAN (1-279): 1.2e-71: 231: 12.90
+	Hs
		1025278 CDK3_HUMAN (1-289): 3.87e-151: 426: 65.40		CCNQ_HUMAN (22-239): 1.1e-67: 216: 25.22
+	Hs
		667568 CDK2_HUMAN (1-293): 2.43e-160: 449: 62.80		CCND2_HUMAN (16-275): 4.2e-58: 193: 15.27
+	Hs
		667665 CDK2_HUMAN (1-293): 2.43e-160: 449: 62.80		CCNH_HUMAN (21-265): 1.1e-57: 193: 17.86
+	Rn
		1048464 Q6P751_RAT (1-293): 5.78e-160: 448: 62.46		CCND2_RAT (16-275): 6.92e-57: 189: 15.27
+	Xl
		561231 CDK1A_XENLA (1-295): 9.3e-147: 415: 69.83		CCNB1_XENLA (1-275): 1.29e-67: 221: 13.09
+	Hs
		908691 CDK3_HUMAN (1-289): 3.87e-151: 426: 65.40		CCNH_HUMAN (21-265): 1.1e-57: 193: 17.86
+	Mm
		718862 CDK2_MOUSE (1-293): 2.15e-151: 428: 53.67		CCND2_MOUSE (16-263): 4.04e-57: 190: 16.67