HitPredict

Interactor 1: PPWD1 (Q96BP3)
Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8) (Spliceosome-associated cyclophilin)
Gene: PPWD1

Interactor 2: SNR40 (Q96DI7)
U5 small nuclear ribonucleoprotein 40 kDa protein (U5 snRNP 40 kDa protein) (U5-40K) (38 kDa-splicing factor) (Prp8-binding protein) (hPRP8BP) (U5 snRNP-specific 40 kDa protein) (WD repeat-containing protein 57)
Gene: SNRNP40

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37689310
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005654 - nucleoplasm GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 357
+	Hs
		656091 PPIB_HUMAN (473-644): 2.66e-74: 239: 44.32		WDR5_HUMAN (95-357): 5.86e-83: 256: 25.09
+	Hs
		1103056 PPIL2_HUMAN (382-645): 2.5e-83: 273: 31.96		SNR40_HUMAN (143-357): 4.86e-57: 191: 19.27
+	Hs
		965276 WDR5_HUMAN (175-406): 7.99e-50: 178: 13.77		NLE1_HUMAN (45-357): 5.57e-87: 272: 21.05
+	Hs
		964797 WDR5_HUMAN (175-406): 7.99e-50: 178: 13.77		WDR5_HUMAN (95-357): 5.86e-83: 256: 25.09
+	Hs
		965071 WDR5_HUMAN (175-406): 7.99e-50: 178: 13.77		WDR5B_HUMAN (4-262): 2.39e-75: 237: 23.31
+	Mm
		1297876 PPIL3_MOUSE (493-645): 1.75e-79: 250: 52.94		A16L1_MOUSE (41-350): 2.92e-34: 134: 29.56
+	Hs
		1227441 PPIL3_HUMAN (493-645): 5.27e-78: 246: 53.60		A16L1_HUMAN (32-344): 8.5e-35: 136: 29.87
+	Hs
		986490 PPIA_HUMAN (486-644): 3.39e-76: 242: 43.56		A16L1_HUMAN (32-344): 8.5e-35: 136: 29.87
+	Hs
		656154 PPIB_HUMAN (473-644): 2.66e-74: 239: 44.32		A16L1_HUMAN (32-344): 8.5e-35: 136: 29.87
+	Mm
		607843 PPIA_MOUSE (486-644): 2.54e-74: 237: 42.95		A16L1_MOUSE (41-350): 2.92e-34: 134: 29.56
+	Hs
		965151 WDR5_HUMAN (175-406): 7.99e-50: 178: 13.77		SNR40_HUMAN (143-357): 4.86e-57: 191: 19.27
+	Hs
		1334151 POC1B_HUMAN (119-484): 3.17e-66: 226: 11.52		POC1A_HUMAN (2-96): 1.31e-16: 82.4: 14.74
+	Hs
		965141 WDR5_HUMAN (175-406): 7.99e-50: 178: 13.77		FBXW7_HUMAN (53-216): 2.88e-28: 117: 27.17
+	Hs
		845264 WDR5_HUMAN (175-406): 7.99e-50: 178: 13.77		LIS1_HUMAN (278-357): 1.05e-18: 88.5: 21.25
+	Hs
		845316 LIS1_HUMAN (255-486): 5.4e-20: 94.7: 10.12		A16L1_HUMAN (32-344): 8.5e-35: 136: 29.87
+	Hs
		845250 LIS1_HUMAN (255-486): 5.4e-20: 94.7: 10.12		LIS1_HUMAN (278-357): 1.05e-18: 88.5: 21.25
+	Mm
		988931 LIS1_MOUSE (255-486): 5.12e-20: 94.7: 10.12		LIS1_MOUSE (278-357): 9.68e-19: 88.5: 21.25
+	Hs
		845346 LIS1_HUMAN (255-486): 5.4e-20: 94.7: 10.12		KTNB1_HUMAN (40-215): 1.21e-14: 77: 33.16