HitPredict

Interactor 1: NET1 (O09118)
Netrin-1
Gene: Ntn1

Interactor 2: UNC5B (Q8K1S3)
Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B)
Gene: UNC5B

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	26633812, 26859457
Identification Methods	pull down, enzyme linked immunosorbent assay, surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	NTR~TSP_1
Common GO terms	GO:0005829 - cytosol GO:0006915 - apoptotic process GO:0007411 - axon guidance GO:0033564 - anterior/posterior axon guidance
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 604 Mm			1 945
+	Hs
		317792 NET1_HUMAN (1-604): 8.42e-176: 513: 99.17		UNC5B_HUMAN (1-945): 0: 973: 92.38
+	Mm
		139747 NET1_MOUSE (1-604): 1.19e-175: 512: 100.00		UNC5C_MOUSE (33-944): 0: 875: 64.15
+	Hs
		306897 NET1_HUMAN (1-604): 8.42e-176: 513: 99.17		UNC5C_HUMAN (33-944): 0: 868: 63.60
+	Dr
		69123 O42140_DANRE (2-604): 4.08e-178: 519: 85.90		A9JR35_DANRE (32-945): 0: 836: 67.46
+	Mm
		140336 NET1_MOUSE (1-604): 1.19e-175: 512: 100.00		UNC5A_MOUSE (1-945): 0: 821: 51.95
+	Mm
		140334 NET1_MOUSE (1-604): 1.19e-175: 512: 100.00		UNC5D_MOUSE (47-944): 0: 804: 51.28
+	Hs
		317791 NET1_HUMAN (1-604): 8.42e-176: 513: 99.17		UNC5A_HUMAN (1-308): 2.59e-45: 178: 57.47
+	Dm
		1098870 NETB_DROME (32-253): 1.38e-49: 186: 53.88		Q9VQ08_DROME (9-237): 5e-27: 121: 19.92
+	Dm
		1099064 NETB_DROME (32-253): 1.38e-49: 186: 53.88		Q9W213_DROME (146-566): 1.95e-14: 80.4: 11.09
+	Hs
		434645 LAMB3_HUMAN (394-582): 8.01e-10: 64.1: 10.67		TSP1_HUMAN (171-436): 4.51e-52: 200: 23.33