HitPredict

Interactor 1: CCL22 (O00626)
C-C motif chemokine 22 (CC chemokine STCP-1) (MDC(1-69)) (Macrophage-derived chemokine) (Small-inducible cytokine A22) (Stimulated T-cell chemotactic protein 1) [Cleaved into: MDC(3-69); MDC(5-69); MDC(7-69)]
Gene: CCL22

Interactor 2: NFKB1 (P19838)
Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
Gene: NFKB1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12820969
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0006954 - inflammatory response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 93 Hs			1 968
+	Hs
		626250 CCL14_HUMAN (8-93): 1.46e-29: 102: 26.74		NFKB1_HUMAN (1-968): 0: 761: 100.00
+	Hs
		626128 CCL11_HUMAN (22-93): 1.1e-24: 90.4: 30.14		NFKB1_HUMAN (1-968): 0: 761: 100.00
+	Hs
		562829 CCL2_HUMAN (21-93): 2.68e-24: 89.7: 25.68		NFKB1_HUMAN (1-968): 0: 761: 100.00
+	Mm
		518939 CCL2_MOUSE (3-93): 5.08e-30: 105: 27.17		NFKB1_MOUSE (1-968): 0: 743: 86.36
+	Mm
		681965 CCL5_MOUSE (3-92): 5.81e-30: 103: 31.11		NFKB1_MOUSE (1-968): 0: 743: 86.36
+	Hs
		626344 CCL19_HUMAN (20-93): 1.56e-20: 80: 27.63		NFKB1_HUMAN (1-968): 0: 761: 100.00
+	Hs
		562890 CCL5_HUMAN (16-92): 1.11e-25: 92.7: 29.87		RELB_HUMAN (30-443): 3.55e-117: 372: 34.37
+	Hs
		142208 CCL22_HUMAN (24-93): 1.18e-23: 87.7: 100.00		RELB_HUMAN (30-443): 3.55e-117: 372: 34.37
+	Hs
		1030018 CCL17_HUMAN (7-92): 1.5e-22: 85: 32.56		RELB_HUMAN (30-443): 3.55e-117: 372: 34.37
+	Hs
		561032 CCL4_HUMAN (3-92): 2.19e-31: 107: 33.33		TF65_HUMAN (28-428): 3.14e-109: 350: 34.07
+	Mm
		518943 CCL2_MOUSE (3-93): 5.08e-30: 105: 27.17		TF65_MOUSE (28-548): 3.13e-108: 348: 27.77
+	Hs
		1045341 CCL14_HUMAN (8-93): 1.46e-29: 102: 26.74		TF65_HUMAN (28-428): 3.14e-109: 350: 34.07
+	Hs
		1007861 X3CL1_HUMAN (5-93): 2.05e-26: 101: 20.23		TF65_HUMAN (28-428): 3.14e-109: 350: 34.07
+	Mm
		723156 CCL5_MOUSE (3-92): 5.81e-30: 103: 31.11		TF65_MOUSE (28-548): 3.13e-108: 348: 27.77
+	Hs
		562891 CCL5_HUMAN (16-92): 1.11e-25: 92.7: 29.87		TF65_HUMAN (28-428): 3.14e-109: 350: 34.07
+	Hs
		562846 CCL2_HUMAN (21-93): 2.68e-24: 89.7: 25.68		TF65_HUMAN (28-428): 3.14e-109: 350: 34.07
+	Hs
		142209 CCL22_HUMAN (24-93): 1.18e-23: 87.7: 100.00		TF65_HUMAN (28-428): 3.14e-109: 350: 34.07
+	Mm
		313426 CCL20_MOUSE (2-92): 9.7e-21: 80.4: 30.11		TF65_MOUSE (28-548): 3.13e-108: 348: 27.77
+	Hs
		562892 CCL5_HUMAN (16-92): 1.11e-25: 92.7: 29.87		REL_HUMAN (35-545): 4.29e-102: 334: 31.24
+	Mm
		723161 CCL5_MOUSE (3-92): 5.81e-30: 103: 31.11		IKBA_MOUSE (541-767): 9.51e-33: 131: 40.00