HitPredict

Interactor 1: ISL2 (Q9CXV0)
Insulin gene enhancer protein ISL-2 (Islet-2)
Gene: ISL2

Interactor 2: PYGO1 (Q9D0P5)
Pygopus homolog 1
Gene: PYGO1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	20211142
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 359 Mm			1 417
+	Hs
		961494 ISL1_HUMAN (14-358): 1.09e-89: 274: 72.75		PYGO1_HUMAN (1-417): 1.94e-62: 209: 85.20
+	Hs
		1382436 ISL2_HUMAN (1-359): 6.56e-88: 270: 98.61		PYGO1_HUMAN (1-417): 1.94e-62: 209: 85.20
+	Mm
		1423985 LHX9_MOUSE (10-324): 1.19e-59: 199: 27.30		PYGO1_MOUSE (1-417): 1.19e-64: 214: 100.00
+	Hs
		895827 LHX2_HUMAN (24-326): 5.5e-61: 202: 26.91		PYGO1_HUMAN (1-417): 1.94e-62: 209: 85.20
+	Hs
		965530 LMO4_HUMAN (15-165): 2.24e-54: 177: 38.13		PYGO1_HUMAN (1-417): 1.94e-62: 209: 85.20
+	Hs
		1379976 LHX4_HUMAN (1-82): 6.1e-18: 86.2: 22.89		PYGO1_HUMAN (1-417): 1.94e-62: 209: 85.20
+	Hs
		895692 LHX2_HUMAN (24-326): 5.5e-61: 202: 26.91		SMCA2_HUMAN (31-348): 1.2e-16: 84.7: 11.91
+	Hs
		895809 LHX2_HUMAN (24-326): 5.5e-61: 202: 26.91		CHD7_HUMAN (3-328): 1.07e-13: 75.4: 13.11
+	Hs
		895693 LHX2_HUMAN (24-326): 5.5e-61: 202: 26.91		SMCA4_HUMAN (31-348): 2.64e-12: 70.8: 11.55
+	Hs
		895758 LHX2_HUMAN (24-326): 5.5e-61: 202: 26.91		KMT2C_HUMAN (71-338): 2.31e-10: 65: 14.69
+	Hs
		1379940 LHX4_HUMAN (1-82): 6.1e-18: 86.2: 22.89		PYGO2_HUMAN (2-417): 1.42e-46: 166: 31.67
+	Hs
		1411577 LHX3_HUMAN (1-82): 7.24e-15: 76.9: 20.48		PYGO2_HUMAN (2-417): 1.42e-46: 166: 31.67
+	Hs
		319090 LMO4_HUMAN (15-165): 2.24e-54: 177: 38.13		SC24D_HUMAN (32-291): 2.96e-09: 61.2: 10.23
+	Hs
		903224 LHX4_HUMAN (1-82): 6.1e-18: 86.2: 22.89		SMCA2_HUMAN (31-348): 1.2e-16: 84.7: 11.91
+	Hs
		1379960 LHX4_HUMAN (1-82): 6.1e-18: 86.2: 22.89		CHD7_HUMAN (3-328): 1.07e-13: 75.4: 13.11
+	Hs
		903272 LHX3_HUMAN (1-82): 7.24e-15: 76.9: 20.48		SMCA2_HUMAN (31-348): 1.2e-16: 84.7: 11.91
+	Hs
		903448 LHX4_HUMAN (1-82): 6.1e-18: 86.2: 22.89		SMCA4_HUMAN (31-348): 2.64e-12: 70.8: 11.55
+	Hs
		1454485 LHX3_HUMAN (1-82): 7.24e-15: 76.9: 20.48		CHD7_HUMAN (3-328): 1.07e-13: 75.4: 13.11
+	Hs
		1338264 LHX4_HUMAN (1-82): 6.1e-18: 86.2: 22.89		KMT2C_HUMAN (71-338): 2.31e-10: 65: 14.69
+	Hs
		1338282 LHX3_HUMAN (1-82): 7.24e-15: 76.9: 20.48		KMT2C_HUMAN (71-338): 2.31e-10: 65: 14.69