HitPredict

Interactor 1: ISL1 (P61371)
Insulin gene enhancer protein ISL-1 (Islet-1)
Gene: ISL1

Interactor 2: PYGO1 (Q9Y3Y4)
Pygopus homolog 1
Gene: PYGO1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0060070 - canonical Wnt signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 349 Hs			1 419
+	Hs
		1382436 ISL2_HUMAN (1-349): 4.2e-81: 252: 73.35		PYGO1_HUMAN (1-419): 1.15e-67: 222: 100.00
+	Mm
		1423866 ISL2_MOUSE (1-349): 4.15e-81: 252: 72.21		PYGO1_MOUSE (1-419): 4.89e-60: 202: 87.35
+	Hs
		895827 LHX2_HUMAN (3-316): 2e-59: 198: 26.10		PYGO1_HUMAN (1-419): 1.15e-67: 222: 100.00
+	Mm
		1423985 LHX9_MOUSE (3-307): 2.58e-59: 197: 26.33		PYGO1_MOUSE (1-419): 4.89e-60: 202: 87.35
+	Hs
		877553 LHX1_HUMAN (16-349): 1.98e-57: 193: 27.35		PYGO2_HUMAN (2-419): 4.2e-47: 168: 32.38
+	Hs
		895809 LHX2_HUMAN (3-316): 2e-59: 198: 26.10		CHD7_HUMAN (20-302): 2.76e-38: 149: 10.71
+	Hs
		877571 LHX1_HUMAN (16-349): 1.98e-57: 193: 27.35		CHD7_HUMAN (20-302): 2.76e-38: 149: 10.71
+	Hs
		965530 LMO4_HUMAN (17-132): 4.02e-25: 101: 40.34		PYGO1_HUMAN (1-419): 1.15e-67: 222: 100.00
+	Hs
		895758 LHX2_HUMAN (3-316): 2e-59: 198: 26.10		KMT2C_HUMAN (38-338): 3.66e-25: 110: 11.68
+	Hs
		877533 LHX1_HUMAN (16-349): 1.98e-57: 193: 27.35		KMT2C_HUMAN (38-338): 3.66e-25: 110: 11.68
+	Hs
		1379976 LHX4_HUMAN (4-73): 6.01e-14: 74.3: 26.76		PYGO1_HUMAN (1-419): 1.15e-67: 222: 100.00
+	Hs
		1229381 LHX8_HUMAN (5-77): 6.47e-10: 61.9: 21.92		PYGO1_HUMAN (1-419): 1.15e-67: 222: 100.00
+	Hs
		1379940 LHX4_HUMAN (4-73): 6.01e-14: 74.3: 26.76		PYGO2_HUMAN (2-419): 4.2e-47: 168: 32.38
+	Hs
		1411577 LHX3_HUMAN (4-341): 7.7e-13: 70.8: 13.37		PYGO2_HUMAN (2-419): 4.2e-47: 168: 32.38
+	Hs
		1229369 LHX8_HUMAN (5-77): 6.47e-10: 61.9: 21.92		PYGO2_HUMAN (2-419): 4.2e-47: 168: 32.38
+	Hs
		1379960 LHX4_HUMAN (4-73): 6.01e-14: 74.3: 26.76		CHD7_HUMAN (20-302): 2.76e-38: 149: 10.71
+	Hs
		1454485 LHX3_HUMAN (4-341): 7.7e-13: 70.8: 13.37		CHD7_HUMAN (20-302): 2.76e-38: 149: 10.71
+	Hs
		1338264 LHX4_HUMAN (4-73): 6.01e-14: 74.3: 26.76		KMT2C_HUMAN (38-338): 3.66e-25: 110: 11.68
+	Hs
		1338282 LHX3_HUMAN (4-341): 7.7e-13: 70.8: 13.37		KMT2C_HUMAN (38-338): 3.66e-25: 110: 11.68
+	Hs
		319090 LMO4_HUMAN (17-132): 4.02e-25: 101: 40.34		SC24D_HUMAN (98-357): 6.34e-10: 63.5: 11.28