HitPredict

Interactor 1: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Interactor 2: AMOL2 (Q9Y2J4)
Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP)
Gene: AMOTL2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	38280479
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005923 - bicellular tight junction and 1 others more... GO:0035329 - hippo signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 400 Hs			1 779
+	Hs
		1197082 WWTR1_HUMAN (1-400): 5.18e-126: 371: 100.00		AMOT_HUMAN (1-740): 2.71e-70: 252: 32.32
+	Hs
		862194 YAP1_HUMAN (14-400): 3.69e-97: 300: 41.13		AMOT_HUMAN (1-740): 2.71e-70: 252: 32.32
+	Hs
		862570 YAP1_HUMAN (14-400): 3.69e-97: 300: 41.13		AMOL2_HUMAN (1-779): 8.18e-72: 252: 100.00
+	Hs
		1314101 WWTR1_HUMAN (1-400): 5.18e-126: 371: 100.00		AMOL1_HUMAN (1-766): 2.7e-42: 168: 40.22
+	Mm
		1354063 WWTR1_MOUSE (1-400): 7.57e-120: 355: 91.00		AMOT_MOUSE (1-661): 2.49e-38: 155: 38.15
+	Hs
		1197083 WWP1_HUMAN (3-386): 5.13e-64: 222: 13.86		AMOT_HUMAN (1-740): 2.71e-70: 252: 32.32
+	Hs
		1430229 WWP1_HUMAN (3-386): 5.13e-64: 222: 13.86		AMOL2_HUMAN (1-779): 8.18e-72: 252: 100.00
+	Hs
		862288 YAP1_HUMAN (14-400): 3.69e-97: 300: 41.13		AMOL1_HUMAN (1-766): 2.7e-42: 168: 40.22
+	Hs
		1197056 ITCH_HUMAN (37-356): 2.66e-60: 211: 14.83		AMOT_HUMAN (1-740): 2.71e-70: 252: 32.32
+	Mm
		862607 YAP1_MOUSE (15-400): 5.46e-100: 307: 41.30		AMOT_MOUSE (1-661): 2.49e-38: 155: 38.15
+	Hs
		1428993 WWTR1_HUMAN (1-400): 5.18e-126: 371: 100.00		CING_HUMAN (175-776): 1.72e-17: 89.7: 9.97
+	Hs
		1428995 WWTR1_HUMAN (1-400): 5.18e-126: 371: 100.00		EP15R_HUMAN (483-673): 1.1e-10: 67.4: 13.09
+	Hs
		773121 YAP1_HUMAN (14-400): 3.69e-97: 300: 41.13		MYH10_HUMAN (56-777): 3.7e-26: 117: 10.67
+	Hs
		776787 YAP1_HUMAN (14-400): 3.69e-97: 300: 41.13		MYH11_HUMAN (207-773): 7.3e-24: 110: 11.36
+	Hs
		772662 YAP1_HUMAN (14-400): 3.69e-97: 300: 41.13		MYH9_HUMAN (222-767): 1.78e-23: 109: 10.87
+	Hs
		1314102 WWP1_HUMAN (3-386): 5.13e-64: 222: 13.86		AMOL1_HUMAN (1-766): 2.7e-42: 168: 40.22
+	Hs
		587586 YAP1_HUMAN (14-400): 3.69e-97: 300: 41.13		DESP_HUMAN (16-454): 4.44e-11: 68.9: 12.02
+	Hs
		862510 YAP1_HUMAN (14-400): 3.69e-97: 300: 41.13		EP15R_HUMAN (483-673): 1.1e-10: 67.4: 13.09
+	Hs
		862149 YAP1_HUMAN (14-400): 3.69e-97: 300: 41.13		PLEC_HUMAN (191-769): 1.21e-09: 64.3: 9.88
+	Hs
		1154155 ITCH_HUMAN (37-356): 2.66e-60: 211: 14.83		ITSN1_HUMAN (136-766): 1.51e-36: 150: 11.46