HitPredict

Interactor 1: WDR76 (Q9H967)
WD repeat-containing protein 76
Gene: WDR76

Interactor 2: CHD8 (Q9HCK8)
Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.-) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1)
Gene: CHD8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31353912
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Helicase_C~WD40, SNF2-rel_dom~WD40
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 626 Hs			1 2581
+	Hs
		965260 WDR5_HUMAN (435-622): 3.17e-42: 157: 12.23		CHD8_HUMAN (1-2581): 0: 2337: 100.00
+	Hs
		1132983 WDR76_HUMAN (1-626): 5.23e-151: 451: 100.00		CHD4_HUMAN (500-2065): 0: 998: 23.41
+	Hs
		243739 WDR76_HUMAN (1-626): 5.23e-151: 451: 100.00		SMCA5_HUMAN (695-1722): 0: 901: 26.43
+	Hs
		1088581 NLE1_HUMAN (181-575): 2.23e-63: 218: 12.47		CHD3_HUMAN (380-2065): 0: 1026: 23.32
+	Hs
		1132879 FBXW7_HUMAN (247-571): 4.45e-61: 217: 13.72		CHD4_HUMAN (500-2065): 0: 998: 23.41
+	Hs
		209257 PRP4_HUMAN (401-624): 8.47e-40: 154: 15.09		CHD3_HUMAN (380-2065): 0: 1026: 23.32
+	Hs
		1088500 SNR40_HUMAN (440-625): 1.14e-33: 134: 11.83		CHD3_HUMAN (380-2065): 0: 1026: 23.32
+	Hs
		964955 WDR5_HUMAN (435-622): 3.17e-42: 157: 12.23		CHD4_HUMAN (500-2065): 0: 998: 23.41
+	Hs
		209266 PRP4_HUMAN (401-624): 8.47e-40: 154: 15.09		CHD4_HUMAN (500-2065): 0: 998: 23.41
+	Hs
		142376 PEX7_HUMAN (308-524): 9.84e-31: 124: 22.02		CHD5_HUMAN (500-2070): 0: 1019: 23.06
+	Hs
		703359 FBXW7_HUMAN (247-571): 4.45e-61: 217: 13.72		SMCA1_HUMAN (693-1705): 0: 899: 26.63
+	Sc
		744366 CMR1_YEAST (159-623): 1.95e-74: 249: 23.50		CHD1_YEAST (663-1846): 0: 853: 27.24
+	Hs
		703360 SNR40_HUMAN (440-625): 1.14e-33: 134: 11.83		SMCA1_HUMAN (693-1705): 0: 899: 26.63
+	Hs
		903450 FBXW7_HUMAN (247-571): 4.45e-61: 217: 13.72		SMCA4_HUMAN (69-1478): 0: 816: 23.14
+	Hs
		160120 FBXW7_HUMAN (247-571): 4.45e-61: 217: 13.72		CHD1_HUMAN (513-1808): 0: 800: 26.81
+	Hs
		903453 SNR40_HUMAN (440-625): 1.14e-33: 134: 11.83		SMCA4_HUMAN (69-1478): 0: 816: 23.14
+	Hs
		160123 SNR40_HUMAN (440-625): 1.14e-33: 134: 11.83		CHD1_HUMAN (513-1808): 0: 800: 26.81
+	Hs
		1350646 FBXW7_HUMAN (247-571): 4.45e-61: 217: 13.72		CHD6_HUMAN (1345-2489): 5.11e-106: 383: 13.93
+	Hs
		1436814 WDR76_HUMAN (1-626): 5.23e-151: 451: 100.00		CHD7_HUMAN (118-704): 2.38e-14: 82: 10.37
+	Ce
		110292 LIN53_CAEEL (251-477): 2.76e-20: 95.7: 15.73		LE418_CAEEL (1876-2045): 7.06e-21: 103: 17.05