HitPredict

Interactor 1: SMUF2 (Q9HAU4)
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: SMURF2

Interactor 2: SMUF1 (Q9HCE7)
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: SMURF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.943

The method score is based on:

Property Details
Experiments 28514442, 27086113, 33961781, 18927080, 37537194, 21897371
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains C2~C2, HECT~HECT, HECT~WW, WW~WW
Common GO terms GO:0004842 - ubiquitin-protein transferase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
and 7 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 748
Hs

1 757
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+ Dm
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Service provided by Combinatics, Japan

Last updated: 11Aug2025