HitPredict

Interactor 1: UBE2C (O00762)
Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UbcH10) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C)
Gene: UBE2C

Interactor 2: PCGF3 (Q3KNV8)
Polycomb group RING finger protein 3 (RING finger protein 3A)
Gene: PCGF3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	19549727
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 179 Hs			1 242
+	Hs
		765340 UB2D2_HUMAN (31-176): 7.97e-80: 235: 34.93		BMI1_HUMAN (3-238): 8.59e-60: 193: 33.76
+	Hs
		623249 UB2D2_HUMAN (31-176): 7.97e-80: 235: 34.93		RO52_HUMAN (2-241): 1.02e-46: 163: 15.56
+	Hs
		1420579 UB2D4_HUMAN (31-176): 3.54e-80: 236: 37.67		TRIM5_HUMAN (2-238): 1.32e-40: 146: 16.60
+	Hs
		1384952 UB2D4_HUMAN (31-176): 3.54e-80: 236: 37.67		TRI43_HUMAN (11-242): 3.54e-38: 139: 15.98
+	Hs
		982276 UB2D2_HUMAN (31-176): 7.97e-80: 235: 34.93		TRI43_HUMAN (11-242): 3.54e-38: 139: 15.98
+	Hs
		1404857 UB2D4_HUMAN (31-176): 3.54e-80: 236: 37.67		RING2_HUMAN (2-237): 1e-35: 131: 18.00
+	Mm
		982385 UB2D2_MOUSE (31-176): 7.97e-80: 235: 34.93		TRI17_MOUSE (2-238): 3.66e-35: 132: 15.41
+	Hs
		1055875 UB2D4_HUMAN (31-176): 3.54e-80: 236: 37.67		RING1_HUMAN (3-172): 7.36e-35: 130: 20.81
+	Hs
		982170 UB2D2_HUMAN (31-176): 7.97e-80: 235: 34.93		RING1_HUMAN (3-172): 7.36e-35: 130: 20.81
+	Hs
		1439327 UB2D4_HUMAN (31-176): 3.54e-80: 236: 37.67		TRI39_HUMAN (8-208): 2.63e-33: 127: 15.94
+	Hs
		1490991 UB2D4_HUMAN (31-176): 3.54e-80: 236: 37.67		TRI17_HUMAN (2-228): 5.88e-33: 126: 15.35
+	Hs
		982282 UB2D2_HUMAN (31-176): 7.97e-80: 235: 34.93		TRI11_HUMAN (2-191): 5.2e-32: 123: 14.36
+	Hs
		1389452 UB2D4_HUMAN (31-176): 3.54e-80: 236: 37.67		CHFR_HUMAN (3-181): 5.56e-31: 121: 16.76
+	Hs
		142704 UB2D4_HUMAN (31-176): 3.54e-80: 236: 37.67		TRI38_HUMAN (2-237): 2.77e-31: 121: 11.88
+	Hs
		572291 UB2D4_HUMAN (31-176): 3.54e-80: 236: 37.67		TRI27_HUMAN (2-237): 4.78e-31: 121: 12.06
+	Hs
		982171 UB2D2_HUMAN (31-176): 7.97e-80: 235: 34.93		TRI26_HUMAN (2-208): 2.97e-31: 122: 15.28
+	Hs
		142676 UB2D2_HUMAN (31-176): 7.97e-80: 235: 34.93		TRI38_HUMAN (2-237): 2.77e-31: 121: 11.88
+	Hs
		571922 UB2D2_HUMAN (31-176): 7.97e-80: 235: 34.93		TRI27_HUMAN (2-237): 4.78e-31: 121: 12.06
+	Hs
		982280 UB2D2_HUMAN (31-176): 7.97e-80: 235: 34.93		CHFR_HUMAN (3-181): 5.56e-31: 121: 16.76
+	Hs
		1458960 UB2D4_HUMAN (31-176): 3.54e-80: 236: 37.67		TRI10_HUMAN (2-195): 2.27e-28: 113: 18.87