Interactor 1: TRXR2 (Q9NNW7)
Thioredoxin reductase 2, mitochondrial (EC 1.8.1.9) (Selenoprotein Z) (SelZ) (TR-beta) (Thioredoxin reductase TR3)
Gene: TXNRD2

Interactor 2: TRXR2 (Q9NNW7)
Thioredoxin reductase 2, mitochondrial (EC 1.8.1.9) (Selenoprotein Z) (SelZ) (TR-beta) (Thioredoxin reductase TR3)
Gene: TXNRD2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 31839598
Identification Methods cross-linking study
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Pyr_redox_2~Pyr_redox_2, Pyr_redox_2~Pyr_redox_dim, Pyr_redox_dim~Pyr_redox_dim
Common GO terms GO:0000305 - response to oxygen radical
GO:0004791 - thioredoxin-disulfide reductase (NADPH) activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
and 11 others

more...

Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 524
Hs

1 524
+ Mm
+ Hs
+ Rn
+ Hs
+ Dm
+ Dm
+ Hs
+ Mm
+ At
+ Sc
+ Sp
+ Ec
+ Ec
+ Sc
+ Mp
+ At

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Last updated: 11Aug2025