HitPredict

Interactor 1: ARFG3 (Q9NP61)
ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3)
Gene: ARFGAP3

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.50	0.533

Property	Details
Experiments	35384245, 34273398
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 516 Hs			1 1620
+	Hs
		464061 ARFG3_HUMAN (1-516): 1.39e-169: 491: 100.00		RET_HUMAN (804-1477): 5.87e-139: 460: 23.15
+	Hs
		179641 ARFG3_HUMAN (1-516): 1.39e-169: 491: 100.00		MUSK_HUMAN (983-1391): 1.78e-119: 399: 29.98
+	Hs
		465659 ARFG3_HUMAN (1-516): 1.39e-169: 491: 100.00		IGF1R_HUMAN (1037-1385): 8.56e-111: 386: 39.77
+	Hs
		464009 ARFG2_HUMAN (2-516): 4.98e-137: 407: 53.61		RET_HUMAN (804-1477): 5.87e-139: 460: 23.15
+	Hs
		179620 ARFG2_HUMAN (2-516): 4.98e-137: 407: 53.61		MUSK_HUMAN (983-1391): 1.78e-119: 399: 29.98
+	Hs
		412650 ARFG3_HUMAN (1-516): 1.39e-169: 491: 100.00		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		1157079 ARFG3_HUMAN (1-516): 1.39e-169: 491: 100.00		NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03
+	Hs
		541702 ARFG3_HUMAN (1-516): 1.39e-169: 491: 100.00		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Hs
		710922 GIT1_HUMAN (17-431): 6.1e-73: 247: 16.15		EPHB2_HUMAN (938-1436): 1.28e-127: 427: 23.26
+	Mm
		1222818 ASAP2_MOUSE (6-410): 6.69e-66: 231: 14.25		ERBB4_MOUSE (882-1541): 6.8e-121: 414: 21.23
+	Hs
		1156997 ARFG2_HUMAN (2-516): 4.98e-137: 407: 53.61		NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03
+	Hs
		207921 ASAP2_HUMAN (6-409): 1.79e-72: 250: 15.66		FAK2_HUMAN (1054-1518): 3.57e-109: 374: 27.45
+	Hs
		1125306 GIT1_HUMAN (17-431): 6.1e-73: 247: 16.15		FAK2_HUMAN (1054-1518): 3.57e-109: 374: 27.45
+	Hs
		541591 ARFG2_HUMAN (2-516): 4.98e-137: 407: 53.61		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Rn
		1000486 ARFG1_RAT (1-416): 1.66e-70: 232: 24.48		FAK2_RAT (1061-1496): 1.5e-111: 381: 29.22
+	Mm
		1455819 ASAP1_MOUSE (2-459): 1.65e-65: 231: 16.21		FAK2_MOUSE (1061-1496): 1.35e-110: 378: 28.31
+	Hs
		207902 ASAP2_HUMAN (6-409): 1.79e-72: 250: 15.66		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		412855 GIT1_HUMAN (17-431): 6.1e-73: 247: 16.15		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		412795 ASAP1_HUMAN (2-459): 1.98e-65: 231: 15.53		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		541752 ASAP1_HUMAN (2-459): 1.98e-65: 231: 15.53		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07