HitPredict

Interactor 1: SAE1 (Q9UBE0)
SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed]
Gene: SAE1

Interactor 2: SAE2 (Q9UBT2)
SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2)
Gene: UBA2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.988

The method score is based on:

Property Details
Experiments 26496610, 17353931, 26264872, 10217437, 10187858, 35271311, 23601649, 35235311, 37071682, 31839598, 9920803, 16189514, 28514442, 33961781, 28524877, 20164921, 21120624, 31515488, 15660128
Identification Methods affinity chromatography technology, enzymatic study, pull down, cross-linking study, two hybrid, molecular sieving, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, two hybrid array, x-ray crystallography and 1 others

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Interaction Type physical association, direct interaction, other modification, sumoylation reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains ThiF~ThiF, ThiF~UAE_UbL
Common GO terms GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0016925 - protein sumoylation
GO:0031510 - SUMO activating enzyme complex
GO:0033235 - positive regulation of protein sumoylation
and 2 others

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Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 346
Hs

1 640
+ Dm
+ Dm
+ Sc
+ Hs
+ Dm
+ Hs
+ Oc
+ Hs
+ Sc
+ Ce
+ Sp
+ Sc

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Last updated: 11Aug2025