Interactor 1: ULA1 (Q13564)
NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1)
Gene: NAE1
Interactor 2: UBA3 (Q8TBC4)
NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3)
Gene: UBA3
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.95 | 1.00 | 0.976 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 15361859, 10722740, 28524877, 18264111, 17220875, 12646924, 12740388, 9694792, 10207026, 29973603, 32296183, unassigned1304 |
| Identification Methods | pull down, two hybrid, cross-linking study, x-ray crystallography, biochemical, fluorescent resonance energy transfer, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | E2_bind~ThiF, ThiF~ThiF |
| Common GO terms | GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019781 - NEDD8 activating enzyme activity GO:0032991 - protein-containing complex GO:0045116 - protein neddylation and 1 others more... |
| Homologous interactions | 14 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
