Protein: ULA1
NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1)

Gene: ULA1, NAE1
Organism: Homo sapiens
Interactions: 59
UniProt ID: Q13564

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
GO:0019781 - NEDD8 activating enzyme activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1110845

UBA3
NEDD8-activating enzyme E1 catalytic subunit

12

14

Small-scale

0.976

High

957361

UBC12
NEDD8-conjugating enzyme Ubc12

9

20

Small-scale

0.973

High

1110836

NEDD8
Ubiquitin-like protein NEDD8

7

4

Small-scale

0.947

High

241612

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.754

High

1110858

UBQL4
Ubiquilin-4

1

7

High-throughput

0.698

High

1110847

UBE2F
NEDD8-conjugating enzyme UBE2F

1

20

Small-scale

0.647

High

422069

A4
Amyloid-beta precursor protein

2

5

Small-scale

0.634

High

970460

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.618

High

1110843

SERB1
SERPINE1 mRNA-binding protein 1

2

4

High-throughput

0.611

High

834304

GARS
Glycine--tRNA ligase

1

1

Small-scale

0.561

High

1110835

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

7

Small-scale

0.561

High

1110844

ZBT44
Zinc finger and BTB domain-containing protein 44

2

2

High-throughput

0.558

High

1085415

SRBP2
Sterol regulatory element-binding protein 2

1

1

High-throughput

0.541

High

1110862

NTNG1
Netrin-G1

1

1

High-throughput

0.536

High

1110864

SAR1B
Small COPII coat GTPase SAR1B

1

3

High-throughput

0.536

High

898230

R144A
E3 ubiquitin-protein ligase RNF144A

1

0

High-throughput

0.513

High

1110863

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.513

High

185673

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

5

High-throughput

0.501

High

1110851

TGS1
Trimethylguanosine synthase

1

0

High-throughput

0.493

High

1110837

ANR39
Ankyrin repeat domain-containing protein 39

1

4

High-throughput

0.489

High

1110850

UIMC1
BRCA1-A complex subunit RAP80

1

1

High-throughput

0.489

High

1110857

LRTM1
Leucine-rich repeat and transmembrane domain-containing protein 1

1

1

High-throughput

0.489

High

218157

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

315562

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

410822

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

2

Small-scale

0.479

High

411887

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

429845

JUN
Transcription factor Jun

1

7

High-throughput

0.479

High

588637

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

606736

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

1107688

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

1110834

ASPP2
Apoptosis-stimulating of p53 protein 2

1

5

Small-scale

0.479

High

1110841

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

1110846

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

1110849

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

1110852

DNJC7
DnaJ homolog subfamily C member 7

1

6

High-throughput

0.479

High

1110854

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

4

Small-scale

0.479

High

1110855

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

1110856

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1110860

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1110861

HERC5
E3 ISG15--protein ligase HERC5

1

9

Small-scale

0.479

High

1110838

DCAF6
DDB1- and CUL4-associated factor 6

1

0

High-throughput

0.458

High

1110848

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

142335

PEX7
Peroxisomal targeting signal 2 receptor

1

4

High-throughput

0.445

High

404783

PRIO
Major prion protein

1

2

High-throughput

0.445

High

910885

IMA1
Importin subunit alpha-1

1

4

High-throughput

0.445

High

1110839

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

1110859

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.445

High

105885

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

259912

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.437

High

695395

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

768129

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

1096676

RFA4
Replication protein A 30 kDa subunit

1

4

High-throughput

0.437

High

886834

CEBPA
CCAAT/enhancer-binding protein alpha

1

5

High-throughput

0.408

High

1103951

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.407

High

1110853

ALG8
Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

1

0

High-throughput

0.282

High

1068900

RIPP1
Protein ripply1

1

0

High-throughput

0.279

Low

1110840

ZN684
Zinc finger protein 684

1

0

High-throughput

0.279

Low

1110842

T183A
Transmembrane protein 183A

1

0

High-throughput

0.279

Low

458912

HEXB
Beta-hexosaminidase subunit beta

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025