HitPredict

Interactor 1: Q9VTQ9 (Q9VTQ9)
AT06668p (Regulatory particle triple-A ATPase 4-related, isoform A) (Regulatory particle triple-A ATPase 4-related, isoform B (EC 5.6.1.5))
Gene: Rpt4R

Interactor 2: Q9VW54 (Q9VW54)
26S proteasome non-ATPase regulatory subunit 2
Gene: Rpn1

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	19079254
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA_lid_3~RPN1_C, AAA_lid_3~RPN1_RPN2_N
Common GO terms	GO:0008540 - proteasome regulatory particle, base subcomplex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 398 Dm			1 919
+	Hs
		1098015 Q53XL8_HUMAN (4-389): 1.8e-138: 404: 41.71		PSMD2_HUMAN (3-917): 0: 1154: 60.89
+	Hs
		968692 PRS4_HUMAN (4-389): 1.8e-138: 404: 41.71		PSMD2_HUMAN (3-917): 0: 1154: 60.89
+	Hs
		1098012 Q53HB3_HUMAN (4-389): 1.6e-137: 401: 41.71		PSMD2_HUMAN (3-917): 0: 1154: 60.89
+	Dm
		875039 PRS4_DROME (1-389): 2.71e-159: 457: 41.13		Q9VW54_DROME (1-919): 0: 1058: 100.00
+	Hs
		851303 PRS6B_HUMAN (9-392): 3.7e-119: 354: 40.89		PSMD2_HUMAN (3-917): 0: 1154: 60.89
+	Dm
		1487645 Q9W414_DROME (5-398): 3.07e-128: 376: 82.49		Q9VW54_DROME (1-919): 0: 1058: 100.00
+	Dm
		1464890 Q9V405_DROME (8-390): 7.84e-128: 375: 40.99		Q9VW54_DROME (1-919): 0: 1058: 100.00
+	Dm
		198105 PRS8_DROME (1-398): 7.83e-124: 365: 42.57		Q9VW54_DROME (1-919): 0: 1058: 100.00
+	At
		1456364 PRS6B_ARATH (11-396): 7.26e-139: 404: 40.93		PSD2A_ARATH (43-919): 0: 1005: 47.98
+	At
		1375897 PRS8B_ARATH (28-393): 5.54e-128: 376: 47.41		PSD2A_ARATH (43-919): 0: 1005: 47.98
+	Sp
		267649 PRS10_SCHPO (13-398): 9.26e-129: 377: 72.02		RPN1_SCHPO (1-919): 0: 982: 45.26
+	Sc
		803658 PRS8_YEAST (15-393): 6.04e-125: 368: 42.48		RPN1_YEAST (47-919): 0: 879: 39.67
+	Hs
		968792 PRS4_HUMAN (4-389): 1.8e-138: 404: 41.71		PSMD1_HUMAN (57-856): 0: 764: 17.41
+	Dm
		874996 PRS4_DROME (1-389): 2.71e-159: 457: 41.13		PSMD1_DROME (57-856): 0: 664: 17.40
+	Hs
		851400 PRS6B_HUMAN (9-392): 3.7e-119: 354: 40.89		PSMD1_HUMAN (57-856): 0: 764: 17.41
+	Hs
		692 PRS6B_HUMAN (9-392): 3.7e-119: 354: 40.89		A0A087WW66_HUMAN (57-856): 0: 697: 17.01
+	Dm
		1464104 Q9W414_DROME (5-398): 3.07e-128: 376: 82.49		PSMD1_DROME (57-856): 0: 664: 17.40
+	Dm
		1464086 Q9V405_DROME (8-390): 7.84e-128: 375: 40.99		PSMD1_DROME (57-856): 0: 664: 17.40
+	Dm
		198065 PRS8_DROME (1-398): 7.83e-124: 365: 42.57		PSMD1_DROME (57-856): 0: 664: 17.40
+	Sc
		740209 PRS8_YEAST (15-393): 6.04e-125: 368: 42.48		RPN2_YEAST (57-863): 0: 617: 17.52