HitPredict

Interactor 1: CHMP5 (Q9VVI9)
Charged multivesicular body protein 5 (Vacuolar protein-sorting-associated protein 60)
Gene: Vps60

Interactor 2: Q9Y162 (Q9Y162)
vesicle-fusing ATPase (EC 3.6.4.6)
Gene: Vps4

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0046718 - symbiont entry into host cell
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 226 Dm			1 442
+	Hs
		1453651 CHMP5_HUMAN (1-222): 1.85e-43: 147: 63.06		VPS4A_HUMAN (6-441): 4.97e-126: 374: 73.85
+	Hs
		276928 CHMP5_HUMAN (1-222): 1.85e-43: 147: 63.06		VPS4B_HUMAN (2-442): 1.93e-125: 372: 74.21
+	Dm
		1345412 CHM4_DROME (7-222): 1.35e-30: 114: 24.42		Q9Y162_DROME (1-442): 9.23e-128: 378: 100.00
+	Hs
		1462137 CHMP3_HUMAN (4-225): 1.04e-30: 114: 15.77		VPS4A_HUMAN (6-441): 4.97e-126: 374: 73.85
+	Dm
		1482284 Q9VN02_DROME (4-219): 4.79e-29: 110: 12.96		Q9Y162_DROME (1-442): 9.23e-128: 378: 100.00
+	Hs
		221893 CHM2A_HUMAN (7-224): 8.52e-28: 106: 16.97		VPS4A_HUMAN (6-441): 4.97e-126: 374: 73.85
+	Hs
		1385915 CHM4C_HUMAN (6-218): 1.52e-26: 104: 20.28		VPS4A_HUMAN (6-441): 4.97e-126: 374: 73.85
+	Hs
		221821 CHM2A_HUMAN (7-224): 8.52e-28: 106: 16.97		VPS4B_HUMAN (2-442): 1.93e-125: 372: 74.21
+	Mm
		857265 CHM2A_MOUSE (7-224): 3.72e-28: 107: 17.43		VPS4B_MOUSE (2-442): 7.58e-125: 371: 75.34
+	At
		102955 F4JXR3_ARATH (1-222): 5.32e-42: 145: 34.33		VPS4_ARATH (4-442): 3.62e-106: 323: 52.24
+	At
		1442474 VP601_ARATH (1-222): 1.27e-41: 142: 40.69		VPS4_ARATH (4-442): 3.62e-106: 323: 52.24
+	Hs
		221889 CHM2A_HUMAN (7-224): 8.52e-28: 106: 16.97		SPAST_HUMAN (62-440): 3.55e-114: 349: 36.84
+	Sc
		781329 DID4_YEAST (7-225): 1.43e-29: 111: 13.84		VPS4_YEAST (1-442): 1.17e-110: 334: 57.21
+	At
		1456765 VPS2A_ARATH (1-215): 2.71e-32: 118: 21.40		VPS4_ARATH (4-442): 3.62e-106: 323: 52.24
+	Sc
		915382 VPS20_YEAST (6-223): 7.56e-27: 104: 19.09		VPS4_YEAST (1-442): 1.17e-110: 334: 57.21
+	Zm
		14250 A0A1D6P3C0_MAIZE (62-223): 4e-29: 112: 27.11		A0A1D6G1D0_MAIZE (78-440): 1.17e-104: 322: 40.16
+	At
		1427505 VP202_ARATH (1-213): 1.41e-26: 103: 19.01		VPS4_ARATH (4-442): 3.62e-106: 323: 52.24
+	Hs
		975481 CHM4C_HUMAN (6-218): 1.52e-26: 104: 20.28		PRS10_HUMAN (9-384): 1.27e-102: 312: 26.62
+	Sc
		680010 VPS60_YEAST (1-207): 2.01e-29: 111: 32.30		CDC48_YEAST (128-437): 4.54e-71: 241: 30.35
+	Hs
		934978 CHM4C_HUMAN (6-218): 1.52e-26: 104: 20.28		TERA_HUMAN (113-437): 4.95e-71: 241: 28.05