HitPredict

Interactor 1: SH21B (O14796)
SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)
Gene: SH2D1B

Interactor 2: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 132 Hs			1 1255
+	Hs
		176340 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		383529 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		ERBB2_HUMAN (1-1255): 0: 1282: 100.00
+	Hs
		176447 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		ERBB4_HUMAN (6-1237): 0: 1098: 45.45
+	Hs
		155844 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		ERBB4_HUMAN (6-1237): 0: 1098: 45.45
+	Hs
		176333 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		155822 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		EGFR_HUMAN (16-1253): 0: 1070: 48.40
+	Hs
		176382 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		ERBB3_HUMAN (5-1254): 0: 1041: 38.55
+	Hs
		155833 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		ERBB3_HUMAN (5-1254): 0: 1041: 38.55
+	Hs
		238330 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		JAK2_HUMAN (216-982): 5.65e-134: 440: 19.75
+	Mm
		763386 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		EPHA4_MOUSE (668-1030): 1.51e-121: 403: 31.45
+	Hs
		412105 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		EPHA4_HUMAN (668-1030): 3.69e-121: 401: 31.45
+	Hs
		176389 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		EPHA2_HUMAN (671-1023): 4.87e-117: 390: 33.06
+	Dm
		382221 SRC42_DROME (3-131): 3.55e-36: 131: 26.52		EGFR_DROME (505-1188): 2.7e-110: 380: 33.53
+	Hs
		176345 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19
+	Hs
		155837 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		FAK1_HUMAN (706-984): 1.9e-53: 206: 39.07
+	Mm
		763399 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		Q8C2G0_MOUSE (707-1006): 2.77e-54: 208: 36.42
+	Hs
		412104 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		EPHA5_HUMAN (707-1010): 2.37e-53: 206: 37.46
+	Mm
		710126 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		FAK1_MOUSE (706-993): 3.91e-53: 205: 38.19
+	Dm
		1360389 SRC42_DROME (3-131): 3.55e-36: 131: 26.52		SRC42_DROME (695-972): 2.54e-52: 194: 40.43
+	Hs
		412015 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		JAK1_HUMAN (674-1035): 3.11e-43: 174: 21.47