HitPredict

Interactor 1: LCK (P06240)
Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	11741956, 8551236, 9115297
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007166 - cell surface receptor signaling pathway GO:0045121 - membrane raft
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Mm			1 913
+	Hs
		411595 LCK_HUMAN (1-509): 0: 634: 96.86		CBL_HUMAN (1-913): 0: 894: 91.05
+	Mm
		435877 HCK_MOUSE (1-509): 0: 592: 64.44		CBL_MOUSE (1-913): 0: 923: 100.00
+	Mm
		610554 FYN_MOUSE (1-507): 0: 590: 53.85		CBL_MOUSE (1-913): 0: 923: 100.00
+	Mm
		536206 FGR_MOUSE (1-507): 0: 587: 53.11		CBL_MOUSE (1-913): 0: 923: 100.00
+	Hs
		412013 FYN_HUMAN (1-507): 0: 591: 54.03		CBL_HUMAN (1-913): 0: 894: 91.05
+	Hs
		442780 HCK_HUMAN (1-509): 0: 591: 65.63		CBL_HUMAN (1-913): 0: 894: 91.05
+	Hs
		454799 FGR_HUMAN (1-507): 0: 579: 52.57		CBL_HUMAN (1-913): 0: 894: 91.05
+	Hs
		433254 YES_HUMAN (1-507): 0: 576: 53.60		CBL_HUMAN (1-913): 0: 894: 91.05
+	Hs
		522778 SRC_HUMAN (2-507): 0: 576: 54.13		CBL_HUMAN (1-913): 0: 894: 91.05
+	Mm
		411924 LCK_MOUSE (1-509): 0: 638: 100.00		CBLB_MOUSE (23-908): 0: 798: 46.14
+	Hs
		411703 LCK_HUMAN (1-509): 0: 634: 96.86		CBLB_HUMAN (23-908): 0: 799: 45.92
+	Rn
		1144046 FYN_RAT (1-507): 0: 589: 53.85		CBLB_RAT (23-908): 0: 810: 47.71
+	Hs
		412170 FYN_HUMAN (1-507): 0: 591: 54.03		CBLB_HUMAN (23-908): 0: 799: 45.92
+	Hs
		433339 YES_HUMAN (1-507): 0: 576: 53.60		CBLB_HUMAN (23-908): 0: 799: 45.92
+	Hs
		522956 SRC_HUMAN (2-507): 0: 576: 54.13		CBLB_HUMAN (23-908): 0: 799: 45.92
+	Hs
		412405 FYN_HUMAN (1-507): 0: 591: 54.03		CBLC_HUMAN (41-502): 0: 629: 42.16
+	Hs
		433504 YES_HUMAN (1-507): 0: 576: 53.60		CBLC_HUMAN (41-502): 0: 629: 42.16
+	Hs
		411582 LCK_HUMAN (1-509): 0: 634: 96.86		MUC1_HUMAN (424-777): 4.11e-10: 66.1: 9.42
+	Hs
		203198 LCK_HUMAN (1-509): 0: 634: 96.86		SYNJ1_HUMAN (565-911): 2.87e-09: 63.4: 13.47
+	Hs
		522749 SRC_HUMAN (2-507): 0: 576: 54.13		MUC1_HUMAN (424-777): 4.11e-10: 66.1: 9.42