HitPredict

Interactor 1: DVL1 (O14640)
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Gene: DVL1

Interactor 2: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	25416956
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0014069 - postsynaptic density GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 695 Hs			1 380
+	Hs
		222045 AFAD_HUMAN (246-658): 1.92e-82: 288: 20.83		NCK2_HUMAN (1-380): 3.54e-95: 290: 100.00
+	Hs
		159667 DVL2_HUMAN (3-695): 8.29e-141: 431: 55.98		ITSN1_HUMAN (5-253): 2.96e-28: 119: 16.61
+	Mm
		465774 DVL2_MOUSE (3-695): 7.21e-142: 434: 56.52		HCK_MOUSE (2-205): 5.54e-22: 99.5: 18.93
+	Hs
		159472 DVL2_HUMAN (3-695): 8.29e-141: 431: 55.98		LYN_HUMAN (2-205): 8.56e-23: 101: 14.56
+	Mm
		431348 DVL2_MOUSE (3-695): 7.21e-142: 434: 56.52		SRC_MOUSE (6-155): 4.82e-19: 90.6: 17.11
+	Hs
		159471 DVL2_HUMAN (3-695): 8.29e-141: 431: 55.98		YES_HUMAN (6-137): 1.81e-19: 91.7: 20.15
+	Mm
		1221219 DVL2_MOUSE (3-695): 7.21e-142: 434: 56.52		GRB2_MOUSE (1-60): 2.89e-18: 84.4: 27.87
+	Hs
		159598 DVL2_HUMAN (3-695): 8.29e-141: 431: 55.98		GRB2_HUMAN (3-60): 5.23e-18: 84: 29.31
+	Mm
		237076 DLG4_MOUSE (104-626): 6.87e-57: 207: 17.60		NCK2_MOUSE (1-380): 5.85e-94: 287: 96.05
+	Hs
		463423 AFAD_HUMAN (246-658): 1.92e-82: 288: 20.83		LYN_HUMAN (2-205): 8.56e-23: 101: 14.56
+	Hs
		463035 AFAD_HUMAN (246-658): 1.92e-82: 288: 20.83		YES_HUMAN (6-137): 1.81e-19: 91.7: 20.15
+	Hs
		557191 AFAD_HUMAN (246-658): 1.92e-82: 288: 20.83		SRC_HUMAN (6-155): 4.28e-19: 90.6: 17.11
+	Hs
		936290 AFAD_HUMAN (246-658): 1.92e-82: 288: 20.83		GRB2_HUMAN (3-60): 5.23e-18: 84: 29.31
+	Hs
		136379 DLG1_HUMAN (23-634): 3e-55: 205: 15.43		P85B_HUMAN (21-380): 2.06e-23: 104: 12.80
+	Mm
		440284 DLG1_MOUSE (23-634): 7.11e-59: 215: 15.72		LCK_MOUSE (3-205): 9.15e-20: 92.5: 16.59
+	Hs
		463488 DLG1_HUMAN (23-634): 3e-55: 205: 15.43		LYN_HUMAN (2-205): 8.56e-23: 101: 14.56
+	Mm
		431355 DLG4_MOUSE (104-626): 6.87e-57: 207: 17.60		SRC_MOUSE (6-155): 4.82e-19: 90.6: 17.11
+	Rn
		723904 DLG4_RAT (104-626): 2.01e-56: 206: 17.60		SRC_RAT (6-155): 4.02e-19: 91: 17.11
+	Hs
		440052 DLG1_HUMAN (23-634): 3e-55: 205: 15.43		LCK_HUMAN (3-205): 1.6e-19: 91.8: 16.59
+	Mm
		1221224 DLG4_MOUSE (104-626): 6.87e-57: 207: 17.60		GRB2_MOUSE (1-60): 2.89e-18: 84.4: 27.87